نتایج جستجو برای: snp array
تعداد نتایج: 154958 فیلتر نتایج به سال:
One of the main advantages of single nucleotide polymorphism (SNP) array technology is providing genotype calls for a specific number of SNP markers at a relatively low cost. Since its first application in animal genetics, the number of available SNP arrays for each species has been constantly increasing. However, conversely to that observed in whole genome sequence data analysis, SNP array dat...
BACKGROUND Tumor single nucleotide polymorphism (SNP) array is a common platform for investigating the cancer genomic aberration and the functionally important altered genes. Original SNP array signals are usually corrupted by noise, and need to be de-convoluted into absolute copy number profile by analytical methods. Unfortunately, in contrast with the popularity of tumor Affymetrix SNP array,...
The emerging discipline of pharmacogenomics applies genomic technologies to predict individuals' responses to therapeutic drugs based on the genetic sequences of drug targets and enzymes involved in drug metabolism. The first diagnostic test for genotyping two important drug metabolizing enzymes (CYP450 2D6 and 2C19) has been FDA approved. This assay involves PCR amplification and identificatio...
Given an m×n haplotype matrix A, we show linear time algorithms for finding all interval diversities, farthest sites, and the longest block with low diversity. For selecting the multiple long blocks with diversity constraint, we show that selecting k blocks with longest total length can be be found in O(nk). We also propose linear time algorithms in calculating the all intra-longest-blocks and ...
BACKGROUND Conventional karyotyping has been a routine method to identify chromosome abnormalities in products of conception. However, this process is being transformed by single nucleotide polymorphism (SNP) array, which has advantages over karyotyping, including higher resolution and dispensing with cell culture. Therefore, the purpose of this study was to evaluate the advantage of high-resol...
We have used new generation sequencing (NGS) technologies to identify single nucleotide polymorphism (SNP) markers from three European pear (Pyrus communis L.) cultivars and subsequently developed a subset of 1096 pear SNPs into high throughput markers by combining them with the set of 7692 apple SNPs on the IRSC apple Infinium® II 8K array. We then evaluated this apple and pear Infinium® II 9K...
Triploidy occurred about 2-3% in human pregnancies and contributed to approximately 15% of chromosomally caused human early miscarriage. It is essential for preimplantation genetic diagnosis and screen to distinct triploidy sensitively. Here, we performed comparative investigations between MALBAC-NGS and MDA-SNP array sensitivity on triploidy detection. Self-correction and reference-correction ...
Highly accurate and reliable genotype calling is an essential component of any highthroughput SNP genotyping technology. BRLMM, the method of choice for the Mapping 500K product, is effective, but requires the presence of mismatched probes (MM) probes on the array to create “seed” genotypes. We present here a method that only uses perfect-match probes, BRLMM-P. The primary difference between BR...
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