The original of this paper repeatedly refers to intravenous ascorbic acid. From talking with Klenner, from talking with his wife, Annie Klenner, who served as his nurse, and from my personal experience, it is clear that he meant sodium ascorbate. See my article on how to make intravenous C solutions. I am especially indebted to Annie Klenner for her descriptions of how Fred made the intravenous...

The mechanism responsible for sodium-hypochlorite-induced reduction in dentin bond strength and its reversal with reducing agents is unknown. This study examined the relationship between nanoleakage and reversal of compromised bonding to oxidized dentin. Acid-etched dentin was completely depleted of demineralized collagen matrix when sodium hypochlorite was used. Specimens were bonded with two ...

Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor whose elevated activity in many cancers helps them to survive under hypoxic conditions and enhances their capacity to grow invasively, establish metastases, and survive chemo- or radiotherapy. Optimal intracellular levels of ascorbate suppress the level and transcriptional activity of HIF-1under normoxic or mildly hypoxic ...

Liposomes have been intensively investigated as carriers for different applications in dermatology and cosmetics. Ascorbic acid has potent antioxidant and anti-inflammatory properties preventing photodamage of keratinocytes; however, due to its instability and low skin penetration, an appropriate carrier is mandatory to obtain desirable efficacy. The present work investigates the ability of a s...

Low flow postural tachycardia syndrome (LFP) is associated with vasoconstriction, reduced cardiac output, increased plasma angiotensin II, reduced bioavailable nitric oxide (NO), and oxidative stress. We tested whether ascorbate would improve cutaneous NO and reduce vasoconstriction when delivered systemically. We used local cutaneous heating to 42°C and laser Doppler flowmetry to assess NO-dep...

freeze-drying is a common preservation technology in the pharmaceutical industry. various studies have investigated the effect of different cryoprotectants on probiotics during freeze-drying. however, information on the effect of cryoprotectants on the stability of some lactobacillus strains during freeze-drying seems scarce. therefore, the aim of the present study was to establish production m...

Purpose: To establish the method for the analysis of rifampin quinone and hydrazone in fixeddose combination tablets (FDC) containing rifampicin with or without sodium ascorbate as an additive. Methods: The International Pharmacopoeial (IP) method for the estimation of rifampin quinone in FDC was modified. The extraction solvent (methanol/buffer mixture) of the IP method was replaced with ethyl...

objective: the present in vitro study was undertaken to compare the effects of hydrogel and solution forms of sodium ascorbate on microleakage of composite restorations subsequent to a non-vital bleaching procedure with 10% carbamide peroxide. materials and methods: forty-eight sound extracted human maxillary incisors were obtained. following root canal therapy, the teeth were randomly divided ...

objective : application of sodium ascorbate as an antioxidant and calcium hydroxide as a buffering agent following intracoronal bleaching has been recommended. the aim of this study was to investigate the effect of using the mentioned materials on shear bond strength of composite resin to the bleached dentin. materials and methods: in this in vitro investigation, sixty human sound premolars wer...