Autosomal recessive proximal renal tubular acidosis is caused by mutations in the SLC4A4 gene encoding the electrogenic sodium bicarbonate cotransporter NBCe1-A. The mutations that have been characterized thus far result in premature truncation, mistargeting, or decreased function of the cotransporter. Despite bicarbonate treatment to correct the metabolic acidosis, extrarenal manifestations pe...

The electrogenic sodium bicarbonate cotransporter (NBCe2) is encoded by SLC4A5, variants of which have been associated with salt sensitivity of blood pressure, which affects 25% of the adult population. NBCe2 is thought to mediate sodium bicarbonate cotransport primarily in the renal collecting duct, but NBCe2 mRNA is also found in the rodent renal proximal tubule (RPT). The protein expression ...

this research was conducted to determine the best temperature for storing different melon cultivars (ghasry, khaghany, tashkandy) and the best concentration and treatment length for immersion in an emulsion of sunflower oil and sodium bicarbonate. after harvest, precooling and sorting, the melons were treated with an emulsion of sunflower oil (3%, 5%) and sodium 2% sodium bicarbonate for 5 or 1...

this experiment was conducted using 216 male chicken (ross 308) to evaluate the effects of organic selenium and sodium bicarbonate supplementation on blood parameters, growth performance and carcass characteristics in heat stress condition. birds were reared under same condition and fed with similar diets till 28 d of age. at 28 days of old, broiler with similar weight were regrouped within die...

The electrogenic sodium bicarbonate cotransporter NBCe1 (SLC4A4) is a robust regulator of intracellular H(+) and a significant base carrier in many cell types. Using wild-type (WT) and NBCe1-deficient (NBC-KO) mice, we have studied the role of NBCe1 in cortical astrocytes in culture and in situ by monitoring intracellular H(+) using the H(+)-sensitive dye BCECF [2',7'-bis-(carboxyethyl)-5-(and-...

Thiazolidinediones (TZDs) are one of the major classes of antidiabetic drugs that are used widely. TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at least, in experimental animals. However, TZDs have side effects, such as edema, congestive heart failure, and bone fracture, and may increase b...