AIM To investigate the role of valproic acid (VPA), a class I selective histone deacetylase inhibitor, on Michigan Cancer Foundation (MCF)-7 breast cancer cells, named and explore its possible molecular mechanism. METHODS MCF-7 cells were cultured with sodium valproate (0. 5-4.0 mmol/L) for 24 h, 48 h, and 72 h in vitro, respectively. The cell viability, apoptosis, and cell cycle were examine...

INTRODUCTION There are few reported cases of neutrophilic pleural effusions associated with valproic acid therapy. Most of them are of eosinophilic exudates with or without blood eosinophilia. CASE PRESENTATION This case study describes a 70-year-old man with recurrent episodes of eosinophilic transudative pleural effusions associated with sodium valproate treatment. The recurrence of effusio...

Valproic acid/sodium valproate (VPA), a drug primarily used for treatment of seizure disorders, is recognized as an efficient epigenetic agent, inducing inhibition histone deacetylases, promoting changes in the methylation status DNA and histones, affecting chromatin structure. In addition to these effects, molecular affinity VPA H1 has been proposed based on thermal denaturation, fluorescence ...

how to cite this article: fallah r, yadegari y, salmani nodushan m. efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital. iran. j. child. neurol 2012;6(2):39-44.   objective status epilepticus (se) is the most common pediatric neurologic emergency with high mortality and morbidity. there is no consensus on the drug of choic...

The carbapenem antimicrobial meropenem has a broad spectrum of activity against most Gram-positive and Gram-negative bacteria, including organisms producing beta-lactamase. It is licensed for several indications in the US and the UK, including pneumonia, skin infections and intra-abdominal infections. Its use to treat urinary tract infections is licensed in the UK but not in the US. Valproic ac...

Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These group...

In a prospective open-label study, the substitution of immediate-release valproic acid for divalproex sodium was evaluated in the treatment of 47 adult psychiatric inpatients who had been stabilized on divalproex for at least one month. After two weeks, no significant change in Clinical Global Impressions scale (CGI) scores or in seizure frequency occurred, and serum valproate concentrations de...

We report a case of tuberous sclerosis in 19 years old teenage patient with generalized tonic-clonic seizure. MRI brain showed linear CSF filled structure surrounding gliosis extending from the frontal horn right lateral ventricle to pial surface lobe-postoperative change. Multiple small T2/ FLAIR hyper-intensities without diffusion restriction bilateral temporal parietal and left occipital lob...