AIM To quantify drug-drug-interactions (DDIs) encountered in patients prescribed hepatitis C virus (HCV) treatment, the interventions made, and the time spent in this process. METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral (DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic...

The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherence of S. pyogenes to epithelial cells. SOF exclusively targets the 30-kDa N-ter...

Notwithstanding the risky, unconventional, and demanding nature of Special Operations Forces (SOF) missions, the assessment and selection of SOF candidates should be governed by the same principles that prevail in the selection of candidates in other sophisticated organizations. This chapter applies western industrial psychology guidelines and procedures to SOF by providing a general overview o...

Out of the four main programming paradigms, it is widely considered that functional most promising. The languages implement paradigm generally do so either in a pure manner, such as Haskell, or by providing multi-paradigm solution, Lisp dialects, order to allow side effects, which are proscribed under former (pure) model. Nevertheless, tracking execution steps program remains challenging for pr...

Serum opacity factor (SOF) is a bifunctional cell surface protein expressed by 40–50% of group A streptococcal (GAS) strains comprised of a C-terminal domain that binds fibronectin and an N-terminal domain that mediates opacification of mammalian sera. SOF is co-transcribed in a twogene operon with another fibronectin-binding protein, SfbX. We compared the ability of an SOF(+) wild-type (WT) se...

Cephalopods provide an unprecedented opportunity for comparative studies of the developmental genetics of organ systems that are convergent with analogous vertebrate structures. The Sox-family of transcription factors is an important class of DNA-binding proteins that are known to be involved in many aspects of differentiation, but have been largely unstudied in lophotrochozoan systems. Using a...

The North Atlantic Treaty Organization (NATO) Special Operations Forces (SOF) Coordination Center (NSCC) is a new NATO memorandum of understanding (MOU) organization that is effecting rapid advancement in NATO's ability to efficiently utilize SOF at the strategic/operational level. The NSCC's lines of development in communications information systems (CIS), education, training, and real life su...

The interferon (IFN)-free regimens for chronic hepatitis C (CHC) have high efficacy and superior health-related quality of life (HRQOL) in European/North American patients. The impact of these regimens on HRQOL of the Japanese CHC patients is not known.The Short Form-36 was administered before, during, and after treatment to CHC patients with genotype 1 treated with ledipasvir/sofosbuvir ± riba...

The Special Operations Force (SOF) medic must have a public health and environmental awareness mindset while conducting operations in any AO. Whether deployed at a Forward Operating Base (FOB) or isolated outpost, the SOF medic can specifically apply two U.S. Army veterinary public health mission priorities--zoonotic disease surveillance and food/water safety. The SOF medic should be knowledgea...

BACKGROUND Comprehensive geriatric assessment (CGA) is a multidimensional tool aimed at detecting multiple age-related problems; the study of osteoporotic fractures (SOF) index is a 3-item instrument designed to measure frailty and pre-frailty status. The aim of this prospective cohort study was to evaluate the accuracy of the SOF index and CGA in predicting the disability status in elderly can...