A combined structural, functional, and genetic approach was used to investigate inhibition of bacterial RNA polymerase (RNAP) by sorangicin (Sor), a macrolide polyether antibiotic. Sor lacks chemical and structural similarity to the ansamycin rifampicin (Rif), an RNAP inhibitor widely used to treat tuberculosis. Nevertheless, structural analysis revealed Sor binds in the same RNAP beta subunit ...

surgery within 24 hours of hip fracture is a critical step in reducing complications, and may decrease mortality compared with conservative care (strength of recommendation [sor]: B, cohort studies). Give patients heparin at the time of admission to prevent venous thromboembolism (vTe) (sor: a, systematic reviews of rCTs). Anticoagulation should be continued in some form for 10 days or until th...

erythromycin has a limited role in treating pediatric patients (strength of recommendation [sOr]: B, limited-quality, patient-oriented evidence). Tegaserod and cisapride are the only prokinetic agents available for constipated adults (sOr: A, consistent, good-quality, patient-oriented evidence for tegaserod; sOr: B, for cisapride), but cardiovascular risk restricts prescribing of both medicatio...

no one treatment is best (strength of recommendation [SOR]: C, meta-analysis of heterogenous studies); no good evidence exists comparing treatments with each other. Triamcinolone injections, triamcinolone injections combined with excision, and cryotherapy all improve hypertrophic and keloid scars (SOR: C, case series studies). Silicone gel products have weak evidence of efficacy (SOR: C, Cochra...

Genes for superoxide reductase (Sor), rubredoxin (Rub), and rubredoxin:oxygen oxidoreductase (Roo) are located in close proximity in the chromosome of Desulfovibrio vulgaris Hildenborough. Protein blots confirmed the absence of Roo from roo mutant and sor-rub-roo (srr) mutant cells and its presence in sor mutant and wild-type cells grown under anaerobic conditions. Oxygen reduction rates of the...

Some sulfate-reducing and microaerophilic bacteria rely on the enzyme superoxide reductase (SOR) to eliminate the toxic superoxide anion radical (O2*-). SOR catalyses the one-electron reduction of O2*- to hydrogen peroxide at a nonheme ferrous iron center. The structures of Desulfoarculus baarsii SOR (mutant E47A) alone and in complex with ferrocyanide were solved to 1.15 and 1.7 A resolution, ...

❚ Evidence summary The prevalence of migraine headache is 6% among men and 15% to 17% among women. However, no standardized approach exists for the treatment of acute migraine headache. Systematic reviews of randomized controlled trials (RCTs) summarized that oral sumatriptan (Imitrex), Medications collectively referred to as “triptans” (eg, sumatriptan, naratriptan, etc) have been shown to be ...

Topical nitrates provide shortterm relief with some side effects, especially headache. Topical nitroglycerin (NTG) patches improve subjective pain scores by about 30% and range of motion over 3 days in patients with acute shoulder tendinopathy (strength of recommendation [SOR]: C, small randomized controlled trial [RCT] with no methodologic flaws). NTG patches, when combined with tendon rehabil...

Successive over-relaxation (SOR) is an important iterative solver for solving linear systems. We present parallel implementations of the red-black SOR method using three modern programming languages, namely Chapel, D and Go. We employ the SOR method for solving a 2D steady-state heat conduction problem. We discuss the optimizations incorporated and the features of these languages which are cruc...