نتایج جستجو برای: sperm chromatin anomalies
تعداد نتایج: 125952 فیلتر نتایج به سال:
background: this case-control study was designed with the aim of evaluating the role of sperm, oxidative stress and dna damage in idiopathic recurrent pregnancy loss (irpl). this pilot study is the first study done on the indian population which reports the association between dfi, tac and ros in couples experiencing irsa. methods: twenty infertile men with a history of irpl and 20 fertile cont...
Background and Aim: Sperm cryopreservation is a common technique used for management of male infertility. But this method has detrimental effects on sperm DNA and chromatin quality. Evaluation of different markers associated with the health of genetic material of sperm is beneficial for determination of the fertility of sperm. The aim of this study was to assess the effect of sperm chromatin co...
Purpose: After aneuploidy, failure of oocyte activation, resulting in premature chromosomal condensation (PCC), is considered as the second cause of failed fertilization post ICSI. Oocyte quality has been shown to affect PCC formation, and since this study sought to evaluate the effect of sperm chromatin anomalies on the PCC, mice metaphase II oocytes were used. Materials and Methods: Metaphas...
introduction: during spermiogendsis, sperm chromatin histones are replaced by protamine. after fertilization, the sprem nucleus is decondenced by glutathione (gsh). in this survey, we study the effect of various concentrations of gsh on human in vitro sperm decondensation. material and methods: after preparation and analysis of semen samples, sperm pellet was washed by ham's f-10 medium twice a...
background: objective: the aim of this study was to investigate the harmful effects of sodium arsenite on sperm parameters and the antioxidant effects of vit.e on sperm anomalies in sodium arsenite treated rats. materials and methods: adult male rats were divided into 4 groups: control, sodium arsenite (8 mg/kg/day), vit.e (100 mg/kg/day) and sodium arsenite+vit.e. oral treatments were perf...
background: there are few studies indicating the detrimental effects of ibuprofen on sperm fertility potential and dna integrity. objective: to determine the effects of ibuprofen on sperm parameters, chromatin condensation and dna integrity of mice. materials and methods: in this experimental study, 36 adult male mice with average weight 37 gr were divided into three groups, including control (...
Introduction: Different studies have shown that there is no relation between sperm chromatin stability and fertilization rate in both IVF and ICSI patients. However, the relation between SDS tests, as a detergent, along with DTT as reducer of disulphide bridges has not been studied so far in ICSI patients. Since different concentrations of DTT can induce different degrees of sperm chromatin dec...
The occurrence of DNA fragmentation in mammalian spermatozoa was identified in 1993. In human, sperm DNA fragmentation is particularly relevant in subfertile patients (i.e, those subjects more likely to be treated by assisted reproductive techniques). Thus, concerns have been raised about the possibility that sperm with DNA fragmentation may be involved in the process of fertilization, in parti...
Background: Selection of human spermatozoa prior to assisted reproduction is currently based on motility and morphology. Recently, Zeta method has been introduced for normal sperm selection based on sperm surface charges. In addition, one of the features of apoptosis is the externalization of phosphatidylserine (PS), which are normally present on the inner leaflet of the sperm plasma membrane. ...
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