BACKGROUND The aims of our study were to investigate the short- and long-term effects of chemo- or radiotherapy on spermatogenesis in patients with testicular cancer and to establish any correlation between pre-therapy sperm parameters, histotype and treatment type/intensity and the progress of spermatogenesis during the post-therapy period. METHODS We evaluated 166 patients affected by testi...

Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive of several meiotic stages and spermiogenesis (terminal spermatozoa differentiation) are transcriptionally inert, indicating the potential importan...

The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of various organs. An important complication of diabetes is the disturbance in the male reproductive system. Glucose metabolism is an important event in spermatogenesis. Moreover, glucose metabolism is also important for maintaining basic cell activity, as well as specific functions, such as motility and fert...

objective(s): nitric oxide (no), a product of inducible nitric oxide synthase (inos), contributes in germ cell apoptosis. this study was aimed to evaluate the effects of aloe vera gel (avg) on male wistar rat reproductive organ, serum no level, and expression of inos gene in leydig cells. materials and methods:adult male wistar rats (n=36) were used for experiments in three groups. the experime...

background: one of the affecting factors in disturbance process of spermatogenesis is chemotherapeutic-induced oxidative stress resulted from cyclophosphamide (cp) treatment which leads to diminished sperm quality via interference in spermatogenesis process. objective: this study was conducted to investigate the effects of ethyl pyruvate (ep) in reducing the cp-induced side effects on reproduct...

BACKGROUND In the human testis, myofibroblasts are the main cellular components of the lamina propria (LP) of seminiferous tubules. Thickened ('fibrotic') LP and dilated tubules are found in a large number of infertile patients, and myofibroblast dedifferentiation has been described in elderly men. It is not known, however, whether dedifferentiation of myofibroblasts is responsible for disturbe...

OBJECTIVE To review the literature and answer questions about semen quality in young cancer patients before and after therapy and the importance of sperm cryopreservation. METHODS All aspects of sperm cryopreservation and effects of therapies on semen quality were examined on the basis of MedLine database searches. RESULTS Chemotherapy, radiation, or their combination results in a significa...

Objective: Age brings about changes to the oxidant and antioxidant balance of male testis that give rise loss fertility. The Ferula elaeochytris root extract (FE), contents anti-inflammatory component, have been used treat infertility by local people for centuries. main objectives this study were determine whether FE was effective on sperm quality, spermatogenesis, apoptosis oxidative stress in...