we assessed the lower urinary tract symptoms (luts) in prostatic cancer patients and investigated the sensitivity and specificity of international prostate symptom score (ipss) in the screening of these patients. a total number of 132 prostatic cancer patients as the case group who were confirmed by the pathologists and 101 noncancerous men as the control group, aged 50 or older, responded to a...

Male breast cancer, consisting only 1% of all breast cancers, is occasionally associated with other primary malignancies, especially in patients with familial breast cancer history. Sporadic male breast cancers with another primary tumor are extremely rare. We report a 67-year-old male with asynchronous bilateral breast cancer and prostate cancer without familial breast cancer history.

One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 (BRCA2) are the genetic events known to date that confer the highest risk of prostate cancer (8.6-fold in men ≤65 years). Although the role of BRCA2 and BRCA1 in prostate tumorigenesis remains unrevealed, deleterious mutations in both genes have...

aim : to investigate association between mthfr gene polymorphism with colorectal cancer. background : the enzyme 5,10-methylene-tetrahydrofolate reductase (mthfr) is linked to dna methylation, synthesis and repair. one of the most important polymorphisms that has been identified in the mthfr gene is c677t. the single nucleotide polymorphism c677t has been found to be associated with decreased e...

3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the HSD3B gene family at 1p13, have long been hypothesized to have a major role in prostate cancer susceptibility. The recent reports of a prostate cancer linkage at 1p13 provided additional evidence that HSD3B genes may be prostate cancer susceptibility genes. To evaluate the possible role of HSD3B genes in prostate cancer, we screened a...

results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...

BACKGROUND. Expression of the a-methylacyl-CoA racemase (AMACR) gene has been established as a sensitive and specific biomarker for the diagnosis of prostate cancer. An initial study has also suggested that the risk of familial (but not sporadic) prostate cancer may be associated with germline variation in the AMACR gene. METHODS. In a study of brothers discordant for the diagnosis of prostate ...

background & aim : prostate cancer is one of the most common cancers in males and the second leading cause of cancer-related deaths in palestine. although, many studies were conducted in de- veloped countries to evaluate quality of life (qol) in survivors of prostate cancer, the researchers could not find any study that was conducted in a developing country including palestine. therefore, the p...

prostate cancer is a major cause of morbidity and mortality in iran, yet there are few studies examining risk factors specific to the iranian context. we conducted a case-control study to explore risk factors for prostate cancer in mazandaran, iran from 2005 to 2008. the cases were 137 men with clinicopathologically confirmed prostate cancer. controls were 137 neighborhood and age match men wit...