Sprue-like enteropathy associated with the angiotensin II receptor blocker (ARB) olmesartan was first described in 2012, and a number of cases have since been reported. This syndrome is characterized by severe diarrhea and sprue-like histopathologic findings in the intestine, often with increased subepithelial collagen. The incidence of this adverse drug reaction is not entirely clear, although...

AIMS A severe syndrome characterised by life-threatening diarrhoea and severe sprue-like histology has been described in patients taking the angiotensin receptor blocker (ARB) olmesartan. It is unknown whether there are any histopathological changes in patients without severe diarrhoea exposed to this medication. It is also unknown whether other ARBs cause sprue-like histology. METHODS Retros...

BACKGROUND/AIMS This study aimed to document the recent etiological spectrum of chronic diarrhea with malabsorption and also to compare features that differentiate tropical sprue from parasitic infections, the two most common etiologies of malabsorption in the tropics. METHODS We analyzed 203 consecutive patients with malabsorption. The etiological spectrum and factors that differentiated tro...

INTRODUCTION Celiac disease can be severe and associated with progressive malabsorption and death. A subset of patients may develop subepithelial collagen deposition, a condition referred to as collagenous sprue. CASE PRESENTATION We report a case of a 46-year-old female who was previously diagnosed as having seronegative arthritis and inflammatory bowel disease, and three years later after t...

Study of immunoglobulin levels in 16 Indian control subjects showed that, compared with a Danish control series, they had a significantly higher mean level of IgG, but not of IgA or IgM. By contrast, the IgG levels in eight patients with tropical sprue were decreased or low normal in six cases and raised in only one case. Two patients with tropical sprue had agamma-A-globulinaemia.Turnover stud...

The dynamics of the rectal surface epithelial lymphocyte and leucocyte response to wheat, gluten, and gliadin enema challenges in control individuals and in patients with coeliac sprue in remission is shown. There is a clear increase in intraepithelial lymphocytes and polymorphonuclear (PMN) leucocytes in response to these enemas in coeliac sprue, but not in controls. The peak response was at e...

In patients with tropical sprue studied both in Puerto Rico and South India, histological changes in gastric mucosa were noted in 67% and 90% of patients respectively (Floch, Thomassen, Cox, and Sheehy, 1963; Vaish, Sampathkumar, Jacob, and Baker, 1965). Besides histological abnormalities, a significant reduction in gastric acid output was also observed. However, these studies did not exclude t...

EVER SINCE 190 8 , when the late Dr. B. K. Ashford' first called attention to its existence in this country, the sprue syndrome has occupied a position of distinction in the medical history of Puerto Rico, and has been the subject of various investigations. Among those contributions dealing with the hematology of sprue , the works of Serra' and J. Suarez" merit special attention, as detailed in...

Celiac disease is a gluten-dependent small intestinal disorder with characteristic, but non-specific histopathological features. A number of disorders may cause similar changes in small intestinal biopsies, but fail to respond to a gluten-free diet. Traditionally, infectious agents, such as giardiasis, were often believed to be responsible, but in many patients with a sprue-like intestinal diso...

By RAM6N M. SUAREZ, M.D., JUAN SABATER, M.D., RAM6N M. SUAREZ, .JR., M.D. AND ROBERTO BUSO, M.D. S PIES and his collaborators,’4 from Cuba and Puerto Rico, as well as several other investigators in various parts of the world, have proved defiusitely the efficacy of vitamin B12 administered intramuscularly in the treatment of sprue. The usual chitsical and hematologic signs and symptoms of acute...