OBJECTIVE To assess gender differences and delay in presentation of childhood squint in a tertiary care hospital. METHODS It was a series of children presenting with squint at the Aga Khan University Hospital, Karachi, Pakistan. We retrospectively studied the cases presenting between February 2000 and July 2007. RESULTS A total of 107 children with squint were seen. Of these, 55 (52.4%) wer...

331 children presenting with pseudostrabismus were assessed retrospectively; 24% of 77 ametropes developed a true convergent squint. Only 1.65% of 243 emmetropes developed a true squint, an incidence much less than in an unselected group. A close follow-up of emmetropic children presenting with pseudostrabismus would seem to be unjustified.

We have used the maternal effect mutant ichabod, which is deficient in maternal beta-catenin signaling, to test for the epistatic relationship between beta-catenin activation, FGF signaling and bozozok, squint and chordin expression. Injection of beta-catenin RNA into ichabod embryos can completely rescue normal development. By contrast, when FGF signaling is inhibited, beta-catenin did not ind...