Individuals with strong self-regulated learning (SRL) skills, characterized by the ability to plan, manage and control their learning process, can learn faster and outperform those with weaker SRL skills. SRL is critical in learning environments that provide low levels of support and guidance, as is commonly the case in Massive Open Online Courses (MOOCs). Learners can be trained to engage in S...

The predicate-argument structure (PAS) of a natural language sentence is a useful representation that can be used for a deeper analysis of the underlying meaning of the sentence or directly used in various natural language processing (NLP) applications. The task of semantic role labeling (SRL) is to identify the predicate-argument structures and label the relations between the predicate and eac...

The Caenorhabditis elegans rol-3(e754) mutation is a member of a general class of mutations affecting gross morphology, presumably through disruption of the nematode cuticle. Adult worms homozygous for rol-3(e754) exhibit rotation about their long axis associated with a left-hand twisted cuticle, musculature, gut and ventral nerve cord. Our laboratory previously isolated 12 recessive lethal all...

Most researches to SRL focus on English. It is still a challenge to improve the SRL performance of other language. In this paper, we introduce a twopass approach to do Chinese SRL with a Recurrent Neural Network (RNN) model. We use English Proposition Bank (EPB) to improve the performance of Chinese SRL. Experimental result shows a significant improvement over the stateof-the-art methods on Chi...

Digital transformation accelerates the undertaking of online learning at various levels education. Online mandates students to have high self-regulation skills. Therefore, self-regulated (SRL) plays an important role in education field. In third wave SRL measurements, there is idea how measurement applied concurrently with intervention. This study proposes a diary that we call Diaria take part ...

Objectives: Sirolimus (SRL) is a widely used immunosuppressive agent in preventing allograft rejection after solid organ transplantation. In this study we established a population pharmacokinetic (PPK) model for SRL in Chinese renal transplant patients, and elucidated the influence of CYP3A5*3 genotypes on SRL PPK parameters and SRL dosing regimen in Chinese renal transplant recipients. Methods...

Sirolimus (SRL) is a mammalian target of rapamycin inhibitor that, in contrast to cyclosporine (CsA), has been shown to inhibit rather than promote cancers in experimental models. At 3 mo +/- 2 wk after renal transplantation, 430 of 525 enrolled patients were randomly assigned to remain on SRL-CsA-steroids (ST) or to have CsA withdrawn and SRL troughs increased two-fold (SRL-ST). Median times t...

The purpose of this study was to compare the effects of sirolimus (SRL) vs cyclosporine (CsA) concerning the cardiovascular mechanisms hypothetically contributing to hypertension development. Three rat groups were studied: control (vehicle), CsA (5 mg/kg/d), and SRL (1 mg/kg/d). The following parameters were evaluated after 7 weeks of treatment: blood pressured (BP) and heart rate (HR; tail cuf...

BACKGROUND/AIMS Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL). METHODS DM was induced by injection of TAC (1.5 mg/kg) or SRL (0.3 mg/kg) for 2 weeks in rats, and MET (200 mg/kg) was i...