G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each contain...

Stacking sequence design of a composite laminate with a given set of plies is a combinatorial problem of seeking an optimal permutation. Permutation genetic algorithms optimizing the stacking sequence of a composite laminate for maximum buckling load are studied. A new permutation GA named gene±rank GA is developed and compared with an existing Partially Mapped Permutation GA, originally develo...

background and objectives: making stacking gels for polyacrylamide gels in the laboratory by conventional methods is laborious and time consuming. considering the role of temperature in polyacrylamide gels with respect to electrical resistance and viscosity, we assumed that decreasing the temperature would cause an increase in electrical resistance and viscosity.  ultimately, a downward tempera...

Foam core sandwich composites are widely used in primary structural components of launch vehicles and spacecraft. These structures exhibit complex failure modes and are highly sensitive to butt-joints, core mismatches, impact damage, voids, and facesheet delaminations. 3D Fiber Reinforced Foam Cores (3DFRFC) represent a new class of core material designed to replace standard foam core in future...

This paper presents a research work on stacking sequence design optimisation for multilayered composite plate using a parallel/distributed evolutionary algorithm. The stacking sequence of fibres has a dramatic influence on the strength of multilayered composite plates. Multiple layers of fibre-reinforced material systems offer versatility in engineering material design due to the fact that the ...

Fapy.dG and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) are formed in DNA by hydroxyl radical damage. In order to study replication past these lesions in cells, we constructed a single-stranded shuttle vector containing the lesion in 5'-TGT and 5'-TGA sequence contexts. Replication of the modified vector in simian kidney (COS-7) cells showed that Fapy.dG is mutagenic inducing primarily targe...

The equilibrium of stacked and unstacked base pairs is of central importance for all nucleic acid structure formation processes. The stacking equilibrium is influenced by intramolecular interactions between nucleosides but also by interactions with the solvent. Realistic simulations on nucleic acid structure formation and flexibility require an accurate description of the stacking geometry and ...