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CDH17 stained 100% (99/99) of colon adenocarcinoma, whereas CK20 and CDX2 stained 92% (91/99) and 96% (95/99), respectively (Figure 1A-C and Figure 2A-C). In stomach adenocarcinoma, CDH17 stained 73% (50/69), CK20 28% (19/69) and CDX2 16% (11/69) (Figure 3A-C) (Table 1). CDH17 was positive in 35% (10/29) of pancreatic ductal cell adenocarcinomas (Figure 4A) (data not shown). All cases of pancre...
Introduction: DNA extraction methods are very important for genetics research and diagnostic tests. In These methods are also important for detecting genetic diseases or in cancers for investigating genetic changes during cancer progression or treatment. Therefore, selection of the best method for DNA extraction from different samples such as bone marrow (BM) or peripheral blood (PB) and their ...
Diagnostic utility of E-cadherin (E-CD) and cytokeratin (CK) subtype profiling in effusion cytology was investigated, employing immunocytochemistry on cellblock sections available from 211 metastatic carcinomas (MC), 6 mesotheliomas and 73 reactive mesothelial hyperplasias (MH). E-CD and monoclonal carcinoembryonic antigen (mCEA) stained 85% (120/141) and 65% (138/211) of MC, respectively. E-CD...
Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro. Recently, we reported that subcutaneous administration of DS inhibits colon inflammation in rats by reducing macrophage and T-cell recruitment and macrophage activation. In t...
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