AIM We tested the hypothesis that statin-related news stories, cardiovascular disease, diabetes, statin dose, calendar year, and socio-demographic status are associated with early statin discontinuation. We also examined frequency and consequences of early statin discontinuation. METHODS AND RESULTS From the entire Danish population, we studied 674 900 individuals aged 40 or older who were in...

Statins improve survival in patients with chronic limb-threatening ischemia (CLTI) but have failed to demonstrate benefit on limb salvage (LS). This study sought identify whether statins may LS among subgroups of CTLI who are at higher risk for major amputation. The Vascular Quality Initiative registry was used undergoing index peripheral vascular intervention (PVI) CLTI between 2010 and 2016. ...

Statin-induced necrotizing autoimmune myopathy is an immune-mediated related to the use of statins. It a very rare disease, which usually presents with proximal muscle weakness and frank elevation in creatine kinase levels. Stopping statin immunosuppressive therapy are considered mainstay therapy. Herein, we present case 75-year-old patient statin-induced based on presence weakness, magnetic re...

OBJECTIVES Statins partially block the production of coenzyme Q10 (CoQ10), an essential component for mitochondrial function. Reduced skeletal muscle mitochondrial oxidative capacity has been proposed to be a cause of statin myalgia and can be measured using 31phosphorus magnetic resonance spectroscopy (31P-MRS). The purpose of this study is to assess the effect of CoQ10 oral supplementation on...

OBJECTIVES The role of statin use in the treatment of acute coronary syndromes (ACS) is not clear. The aim of our study was to evaluate the role of statins in ACS. METHODS Using data from the Acute Myocardial Infarction in Switzerland (AMIS Plus) Project, we compared the effects of chronic statin use, statin therapy after admission and no statin therapy on presentation mode and outcomes in AC...

OBJECTIVES To detect the efficacy and safety of combined lipid-regulating therapies in the very old patients with mixed dyslipidemia and determine an appropriate therapy for them. METHODS Four hundred and fifty patients aged over 75 with mixed dyslipidemia were divided into five groups according to different combination therapies. Lipid levels and drug related adverse events were tested durin...

BACKGROUND Guidelines suggest statin use after acute myocardial infarction (AMI) should be close to universal in patients without safety concerns yet rates are much lower than recommended, decline with patient complexity, and display substantial geographic variation. Trial exclusions have resulted in little evidence to guide statin prescribing for complex patients. OBJECTIVE To assess the ben...

Muscle problems and other adverse symptoms associated with statin use are frequent reasons for non-adherence and discontinuation of statin therapy, which results in inadequate control of hyperlipidemia and increased cardiovascular risk. However, most patients who experience adverse symptoms during statin use are able to tolerate at least some degree of statin therapy. Given the profound cardiov...

Statin adalah golongan hiperlipidemia yang paling umum dilaporkan terkait kejadian myalgia dengan dosis 10-80 mg/hari. Kejadian diinduksi statin menjadi perhatian bagi peneliti, mengingat jumlah pasien hiperkolesterolemia menggunakan terapi cukup tinggi. Penelitian bertujuan untuk mengetahui berpotensi menyebebkan serta tingkat keparahan akibat penggunaan statin, sehingga dapat meningkatkan kew...

BACKGROUND Published studies regarding statin-associated myopathy may describe more dramatic patient presentations, potentially leading to inaccurate characterization of the condition. Furthermore, long-term outcomes and responses to statin rechallenge in patients with statin-associated myopathy are largely unknown. METHODS The University of Wisconsin Hospital and Clinics Medical Informatics ...