Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealt...

Haptides are 19-21mer cell-binding peptides equivalent to sequences on the C-termini of fibrinogen beta chain (Cbeta), gamma chain (preCgamma) and the extended alphaE chain of fibrinogen (CalphaE). In solution, Haptides accumulated in cells by non-saturable kinetics [Exp. Cell Res. 287 (2003) 116]. This study describes Haptide interactions with liposomes and Haptide-mediated liposome uptake by ...

Ultrasound active liposomes currently have gained a lot of interest as therapeutic agents for targeted drug delivery. A well known problem is their fast clearance from the circulation and thus the short time frame for drug release. The use of ultrasound as external trigger for drug release is attractive because it can be easily focused and only few adverse effects on the healthy tissue can be o...

BACKGROUND Effective anticancer drug delivery to the tumor site without rapid body clearance is a prerequisite for successful chemotherapy. 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-(methoxy[polyethyleneglycol]-2000) (DSPE-PEG2000) has been widely used in the preparation of stealth liposomes. Although PEG chains can efficiently preserve liposomes from rapid clearance by the reticuloend...

Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and mushroom-to-brush conformational transition and (ii) of the liposome/micelle ratio in the film-forming dispersions, on the int...

While network-level multicast has tremendous potential for increasing the efficiency of group-oriented applications, the adoption of network-level multicast has been tepid at best. In this paper, we propose a novel concept entitled stealth multicast that allows for practical adoption of network-level multicast on a domain-wise basis rather than global scale. In the stealth multicast model, simi...

We propose and experimentally demonstrate a wavelength-division multiplexed (WDM) optical stealth transmission system carried by amplified spontaneous emission (ASE) noise. The stealth signal is hidden in both time and frequency domains by using ASE noise as the signal carrier. Each WDM channel uses part of the ASE spectrum, which provides more flexibility to apply stealth transmission in a pub...