BACKGROUND AND PURPOSE This review discusses the state of our current knowledge on hemorrhagic transformation (HT) and summarizes key factors to be considered when comparing risk associated with various approaches to revascularization. SUMMARY OF REVIEW HT is a common and natural consequence of infarction, likely related to matrix metalloproteinases and free radical pathways disrupting permea...

A new species of Aspilota without mesoscutal pit, Aspilota isfahanensis Peris-Felipo, sp. n., is described and illustrated from Iran. The new species is compared with its three morphologically most similar species, Aspilota compressiventris Stelfox & Grahan, 1951, Aspilota makita Papp, 2008 and Aspilota spiracula Munk & Peris-Felipo, 2013, is provided. A key to the western Asian species of Aspi...

Preclinical studies suggest that augmentation of selective serotonin (5-HT) reuptake inhibitors by the 5-HT(1A) receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response, an effect largely mediated by blockade of 5-HT(1A) autoreceptors in the dorsal raphe nuclei. Although some controlled clinical trials suggest that pindolol might reduce latency ...

A decreased level of brain 5-hydroxytryptamine (5-HT) has been theorized to be a core pathogenic factor in depression for half a century. The theory arose from clinical observations that drugs enhancing extracellular levels of 5-HT (5-HTExt) have antidepressant effects in many patients. However, whether such drugs indeed correct a primary deficit remains unresolved. Still, a number of anomalies...

Hyperthermia (HT)--heating the tumor in the range of 40.0- 44.0 °C--combined with radiation (RT) and/or chemotherapy (CT) is a well proven treatment for malignant tumors. The improvement of the techniques for monitoring and adapting of the desired temperatures even in deep seated tumors has led to a renaissance of, now quality-controlled, HT in multimodal tumor therapy approaches. Randomized cl...

INTERACTIONS BETWEEN PHYSIcians and the pharmaceutical industry have received increasing amounts of attention over the last several years. Several authors have described significant contact between the pharmaceutical industry and academic researchers, faculty physicians, community physicians, residents, and medical students. More importantly, these types of interactions have been shown to influ...

Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduc...

Derek J Roberts ([email protected]) Simon Leigh-Smith ([email protected]) Peter D Faris ([email protected]) Chad G Ball ([email protected]) Helen Lee Robertson ([email protected]) Christopher Blackmore ([email protected]) Elijah Dixon ([email protected]) Andrew W Kirkpatrick (Andrew.Kirkpatrick@a...

BACKGROUND The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs). AIM To perform a systematic review of the safety profile, particularly cardiovascular, of 5-HT(4) agonists developed for gastrointestinal disorders, and a nonsystematic summary of their pharmacology and clinical efficacy. METHODS Articles reporting da...

Serotonin (5-HT) induces concentration-dependent metabolic effects in diverse cell types, including neurons, entherochromaffin cells, adipocytes, pancreatic beta-cells, fibroblasts, smooth muscle cells, epithelial cells, and leukocytes. Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT...