Pluripotent stem cells can undergo repeated self-renewal while retaining genetic integrity, but they occasionally acquire aneuploidy during long-term culture, which is a practical obstacle for medical applications of human pluripotent stem cells. In this study, we explored the biological roles of ABR, a regulator of RHO family small GTPases, and found that it has pivotal roles during mitotic pr...

introduction: noonan syndrome (ns) is a heterogeneous genetic disease that affects many parts of the body. it was named after dr. jacqueline anne noonan, a paediatric cardiologist.case report: we report audiological tests and auditory brainstem response (abr) findings in a 5-year old malay boy with ns. despite showing the marked signs of ns, the child could only produce a few meaningful words. ...

BACKGROUND The purpose of this study was to evaluate the auditory brain stem response (ABR) and acoustic emissions of the inner ear (OAE) in middle-aged type 2 diabetics. METHODS Fifty type 2 diabetic and nondiabetic patients aged 40-50 years and attending the Tabriz Medical University outpatient clinics were recruited for this study during 2009-2010. All ABR and OAE procedures were implement...

The current status of the application of the fast Fourier transform (FFT) for the auditory evoked response was summarised under for items of importance to the auditory brain stem response (ABR) as follows. (1) Digital filter: The most common way to use FFT, which facilitates quick isolation of fast and slow components from data of the same ABR wave. In addition, the proper setting of digital fi...

Objective To assess the role of single and repeated auditory brain stem response (ABR) in predicting mortality and severe neurological injury among children having bacterial meningitis (BM) in Luanda, Angola. Methods The morphology of ABR traces of 221 children (aged 2 months to 12 years) from admission day was analyzed and compared with age-matched normative data. Absence and delay of traces...

In mice, the auditory brainstem response (ABR) is frequently used to assess hearing status in transgenic hearing models. The diagnostic value of the ABR depends on knowledge about the anatomical sources of its characteristic waves. Here, we studied the contribution of the inferior colliculus (IC) to the click-evoked scalp ABR in mice. We demonstrate a non-invasive correlate of the IC response t...

We have used dipole localization methods (DLMs) to examine multielectrode acoustic brain-stem response (ABR) data for 9 data files collected in 5 experiments on 2 cats. The analytical model for scalp surface voltage consisted of a single current dipole in a homogeneous spherical head model. DLM sources were compared to ABR generator sites determined in intracranial and lesion experiments descri...

BACKGROUND Neonatal jaundice is a common cause of sensorneural hearing loss in children. OBJECTIVES We aimed to detect the neurotoxic effects of pathologic hyperbilirubinemia on brain stem and auditory tract by auditory brain stem evoked response (ABR) which could predict early effects of hyperbilirubinemia. PATIENTS AND METHODS This case-control study was performed on newborns with patholo...

Our previous study demonstrated rapamycin added to diet at 4 months of age had significantly less age-related outer hair cell loss in the basal half cochlea 22 compared mice without rapamycin. The present tested adding later life, 14 age, and a longitudinal assessment auditory brain stem response (ABR). used UMHET4 mice, way cross which all grandparental strains lack Cdh23 753A allele that pred...