نتایج جستجو برای: sterol regulatory elementbinding transcription factor 1
تعداد نتایج: 3558966 فیلتر نتایج به سال:
Fatty acid metabolism is transcriptionally regulated by two reciprocal systems: peroxisome proliferator-activated receptor (PPAR) controls fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis. To explore potential interactions between LXR and PPAR, the effect of LXR activation on PPAR signaling was invest...
Cholesterol biosynthesis in somatic cells is controlled at the transcriptional level by a homeostatic feedback pathway involving sterol regulatory element binding proteins (SREBPs). These basic helix-loop-helix (bHLH)-Zip proteins are synthesized as membrane-bound precursors, which are cleaved to form a soluble, transcriptionally active mature SREBP that regulates the promoters for genes involv...
multiple sclerosis (ms) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (cns), which mainly affects young adults. activated t lymphocytes promote the neuro-inflammatory cascade of ms by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. t lymphocytes may trigger the inflammation, which in turn leads to axonal...
Journal of Lipid Research Volume 53, 2012 1359 Copyright © 2012 by the American Society for Biochemistry and Molecular Biology, Inc. unusual in that they have three, rather than two, sources of cholesterol. Enterocytes uniquely absorb free cholesterol from the gut lumen, and they also share two ubiquitous sources with other cells: endogenous synthesis of sterols de novo and uptake of LDL-derive...
Expression of the GLUT4 (glucose transporter type 4 isoform) gene in adipocytes is subject to hormonal or metabolic control. In the present study, we have characterized an adipose tissue transcription factor that is influenced by fasting/refeeding regimens and insulin. Northern blotting showed that refeeding increased GLUT4 mRNA levels for 24 h in adipose tissue. Consistent with an increased GL...
Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1. PMA and ionomycin likewise increased LDL recep...
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