background : deep brain stimulation (dbs) of the globuspallidusinternus (gpi) is recommended as a promising technique for the management of the primary generalized dystonia (pgd) with dyt1 gene mutation. we present the first report of dbs results in iranian patients with dyt1 positive pgd.   methods : nine patients who suffered from severely disabling dyt1 positive pgd consecutively were recrui...

In a clinical application, a method for an examination of a vibratory sense is not very objective and it depends on an active cooperation of a patient, which cannot be achieved in every situation. The aim of this research is to define parameters of an evoked potentials method with a vibratory stimulation technique which would establish reliable and repeatable results applicable in a clinical us...

PURPOSE There is significant variation in how patients respond to cortical electrical stimulation. It has been hypothesized that individual demographic and pathologic factors, such as age, sex, disease duration, and MRI findings, may explain this discrepancy. The purpose of our study is to identify specific patient characteristics and their effect on cortical stimulation, and discover the exten...

  Background : Deep brain stimulation (DBS) of the globuspallidusinternus (GPi) is recommended as a promising technique for the management of the primary generalized dystonia (PGD) with DYT1 gene mutation. We present the first report of DBS results in Iranian patients with DYT1 positive PGD.   Methods : Nine patients who suffered from severely disabling DYT1 positive PGD consecutively were recr...

Peripheral nerve trauma impacts both social and occupational quality of life. Patients are typically young subsequently suffer from lifelong disability. Unlike the central nervous system, peripheral system has capacity to regenerate along previous or new connections. Yet, complete functional recovery been an elusive clinical objective despite development advanced microsurgical techniques repair...

objective: low-frequency stimulation (lfs) exerts suppressive effects in kindled animals. it is believed that overstimulated glutamatergic and decreased gabaergic transmission have long been associated with seizure activity. in this study, we investigated the effect of electrical lfs on different parameters of spontaneous excitatory and inhibitory post-synaptic currents (sepscs and sipscs) in h...

Objective(s): Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. Material and Methods: Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

during the past .. years, non-invasive .rain stimulation has .ecome an emerging .eld in clinical neuroscience due to its capability to transiently modulate corticospinal excitability, motor and cognitive functions. .hereas transcranial magnetic stimulation has .een used e.tensively since more than t.o decades ago as a potential .neuromodulator., transcranial current stimulation .tcs. has more r...