Newer chemotherapeutic agents target extracellular signaling, including the mitogen-activated protein kinase kinase (MEK) pathway. We present a case of a 54-year-old female who developed bilateral multifocal central serous-like chorioretinopathy shortly after starting MEK inhibition for metastatic cutaneous melanoma. There was a complete resolution of findings after drug stoppage. After resumin...

We investigate whether the recent slow-down of Whillans Ice Stream (WIS),West Antarctica, may lead to its complete stoppage in the near future, using a numerical model. Basal resistance to ice-stream motion is represented by a continuous till layer whose strength changes in response to basal melting and freezing.We implement a basal drainage system, which acts to hinder ice-stream stoppage thro...

Recent studies have suggested that global mean surface temperature would remain approximately constant on multicentury timescales after CO2 emissions1–9 are stopped. Here we use Earth system model simulations of such a stoppage to demonstrate that in some models, surface temperature may actually increase on multi-century timescales after an initial century-long decrease. This occurs in spite of...

OBJECTIVES To evaluate the impact of clinical response on work stoppage or work absence among employed people with early RA. METHODS First-year data from the combination of MTX and etanercept trial was used. The analyses were restricted to the 205 patients working full or part time at baseline who answered questions on whether they stopped working or missed days from work in one or more of th...

Objectives. To evaluate the impact of clinical response on work stoppage or work absence among employed people with early RA. Methods. First-year data from the combination of MTX and etanercept trial was used. The analyses were restricted to the 205 patients working full or part time at baseline who answered questions on whether they stopped working or missed days from work in one or more of th...

We show how the application of a coupling field connecting the two lower metastable states of a Lambda system facilitates stoppage of light in a coherently driven Doppler broadened atomic medium via electromagnetically induced transparency.

Escherichia coli FtsK is a powerful, fast, double-stranded DNA translocase, which can strip proteins from DNA. FtsK acts in the late stages of chromosome segregation by facilitating sister chromosome unlinking at the division septum. KOPS-guided DNA translocation directs FtsK towards dif, located within the replication terminus region, ter, where FtsK activates XerCD site-specific recombination...