Aim. To study the effect of eplerenone on activity free radical oxidation and renal function in rats with experimental diabetes mellitus induced by streptozotocin. Materials methods . Experiments were carried out 36 male Wistar rats. Diabetes (DM) was simulated a single intraperitoneal injection streptozotocin at dose 65 mg/kg. Eplerenone injected into stomach 50 Results. It found that diabetic...

Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated d...

Objective(s): Reproductive dysfunction is a consequence of diabetes. Diabetes is associated with changes in testicular tissue. Sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin E, and monounsaturated fatty acid (MUFA). The present study investigated the effects of sesame on testis histology and male reproductive parameters in streptoz...

background: royal jelly has been shown to have antioxidant and antidiabetic effects. the objective of this study was to evaluate the protective effect of rj against kidney damage in streptozotocin induced diabetic rats. methods: thirty two male wistar rats were divided randomly into four groups (n=8 per group). normal control and diabetic control groups received 1cc/day distilled water, normal ...

We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (-/-) mice. Initial studies showed that streptozotocin, in the abs...

Diabetes is a metabolic disorder characterized by persistent high glucose level. Linum usitatissimum (flaxseed) which rich in fibre and essential fatty acid one of the functional foods used management diabetes mellitus. The aim this study to evaluate antidiabetic effect L. usititatissimum seed leaf stem on streptozotocin induced diabetic rats see part more potent diabetes. Thirty (30) albino we...

Objective: The aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (STZ)-induced diabetes mellitus). Materials and Methods: Five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...

abstract diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. this study was to investigate alcoholic extract effect of alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. in this study, 28 wistar male rats were divided into the four groups (n = 7): non-diabetic contro...

The alcoholic extract of Swertia chirayita was tested for its biochemical and pathomorphological effects in streptozotocin induced diabetes rats. Streptozotocin produced effectively all the animals at 45 mg/kg b.w. intraperitonially. diabetic showed significant increase serum levels glucose, cholesterol, triglycerides, ALT AST a reduction insulin levels. treated rats dose 500 b.w with improveme...

Objective: Diabetes Mellitus (DM) is one of the leading causes of death, illness, and economic loss in the world. The present study was attempted to evaluate extract of Foeniculum vulgare (fennel) on lipid profile, lipid peroxidation and activities of amino transferase enzymes in streptozocin induced diabetic adult male rats. Materials and Methods: The effects of daily oral administration of...