OBJECTIVE(S) Crocin influences many biological functions including memory and learning. The present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. MATERIALS AND METHODS Diabetes was induced by intraperitoneal (IP) injection of streptozotocin (STZ, 45 mg/kg). Transfer latency (TL) paradigm in elevated plus-maze ...

PURPOSE Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies. EXPERIMENTAL DESIGN Human GEP-NETs were tested for a...

Background: The experimental model of streptozotocine (STZ)-induced diabetes explains changes in the male reproductive system as part of the disease. Objective: The aim of the present study was to evaluate the olive leaf extract effects on STZ-induced diabetes and to examine its modulatory effects on sperm quality. Methods: Twenty adult male Sprague–Dawley rats were divided into four equal grou...

The present study aimed to investigate the effects of pueraria on streptozotocine (STZ)-induced renal damage and its possible mechanisms. Wistar rats were randomly divided into five groups: the normal control group, diabetes untreated model group, two dosages (140 and 200 mg per kg bw per day) of puerarin treatment groups and a positive control group. Rats were studied 30 days after the STZ tre...

      The search for indigenous natural antidiabetic agents is still ongoing. Securigera securidaca seeds are reputed in folk medicine for their value as an antidiabetic remedy, so the present study was carried out to investigate the hypoglycemic efficacy in both normal and streptozotocine (STZ)-induced diabetic rats. Hydroalcoholic extract of the seeds were administe...

BACKGROUND The peroxisome proliferator activating nuclear receptors (PPAR) are activated in the context of inflammation, diabetes or normal pregnancy. Renal mesangial cells express PPAR-gamma which upon activation are capable of exerting anti-inflammatory effects. We investigated the effect of in vivo treatment by rosiglitazone on angiotensin II (A-II) stimulated manifestations of inflammation ...

Aims The intraportal pancreatic islet transplantation (IPIT) model of diabetic rats is an insulin mediated model of hepatocarcinogenesis characterized by the induction of clear cell foci (CCF) of altered hepatocytes, which are pre-neoplastic lesions excessively storing glycogen (glycogenosis) and exhibiting activation of the AKT/mTOR protooncogenic pathway. In this study, we transferred the IPI...

objective(s): crocin influences many biological functions including memory and learning. the present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. materials and methods: diabetes was induced by intraperitoneal (ip) injection of streptozotocin (stz, 45 mg/kg). transfer latency (tl) paradigm in elevated plus-maze ...