The detection of local structural patterns in proteins (e.g. active sites) can provide insights into protein function in the absence of sequence or fold similarity. Methods to detect such similarities are key during structural annotation, for example with results from Structural Genomics initiatives. PINTS (Patterns in Non-homologous Tertiary Structures, http://pints.embl.de) performs database ...

This paper considers experimental information on the atomic arrangements in non-crystalline single element films of transition and coinage metals prepared by vapour quenching and compares this information with results from recently reported structural models. The method of structural analysis using transmission electron diffraction is outlined and several recent experimental investigations are ...

In order to understand the phenomenon of longevity in biological world, the relationship between the potential of longevity of an organism and its structural complexity is analyzed. I. Potential of longevity is the maximum longevity of an organism if it lives in an ideal environment. Longevity of an organism includes the time for development (developing time) and the time for structure-maintena...

Alphavirus-based replicon systems are frequently used as preclinical vectors and as antigen discovery tools, and they have recently been assessed in clinical vaccine trials. Typically, alphavirus replicon RNAs are delivered within virus-like replicon particles (VRP) that are produced following transfection of replicon RNA and two helper RNAs into permissive cells in vitro. The non-structural pr...

As a service organization, for an academic institution, knowledge sharing is a critical process that needed to be done and developed always in order to achieve sustainable advantage, emphasizing its role as center of excellence. The research objection was to explore the relationship between the three constructs: Knowledge Sharing, Absorptive Capacity and Channel Richness. The conceptual and str...

This study aims to explore the causal relationship between e-word-of-mouth (e-WOM) and its influence on purchase decisions through structural equation modeling (SEM). Five constructs were formulated through literature review: expertise, search extent, own experience, trustworthiness, and e-WOM effect. Results of this study show that four constructs all have positive influence on e-WOM effect, a...

In this paper, we propose the use of metadata to define the perceptual weight of semantically meaningful regions in video frames for video quality assessment. The proposed approach is evaluated using the structural similarity (SSIM) index metric and a comparison is made with both the unweighted approach and the luminance-based weighted approach. Experimental results demonstrate that the propose...

The present study first aimed to construct a coactivation model that integrates cognitive and motivational variables that determine an individual’s conscious humor experience. It then aimed to test the model’s reliability, validity, and generalizability. As part of the study, 16 (out of 48) four-frame cartoons were randomly presented to 201 (42 male and 159 female) high school students and 302 ...

This chapter presents a review of applications of structural equation modeling (SEM) published in psychological research journals in recent years. We focus first on the variety of research designs and substantive issues to which SEM can be applied productively. We then discuss a number of methodological problems and issues of concern that characterize some of this literature. Although it is cle...