With the rising prevalence of diabetes mellitus around world, researchers have been searching for a new treatment option that is both more effective and safer than chemotherapy. This study evaluated antidiabetic activities aqueous extracts Eclipta prostrataL. in streptozotocin (STZ)-induced diabetic rats. The rats were randomized into six groups: Normal control, STZ-induced (50 mg/kg), STZ + EP...

Purpose: To investigate the neuroprotective effect of natural flavonoid rhoifolin in rats with streptozotocin (STZ)-induced (AD).
 Methods: Morris water-maze and novel object recognition tests were carried out to estimate on memory cognition. Histopathological analysis was made observe thickness hippocampal CA1 pyramidal layer. Analysis oxidative stress markers performed hippocampus fronta...

To investigate whether Ang II type-1 (AT1) receptor blockade could protect kidney mitochondria in streptozotocin-induced type-I diabetes, 8-week-old, male Sprague-Dawley rats received: a single streptozotocin injection (65 mg/kg, i.p.) (STZ group); streptozotocin and drinking water containing losartan (30 mg/kg/d) (STZ+Los group), or amlodipine (3 mg/kg/d) (STZ+Amlo group); or saline (i.p.) and...

Chronic hyperglycemia in type-1 diabetes mellitus is associated with oxidative stress (OS) and sudden death. Mechanistic links remain unclear. We investigated changes in electrophysiological (EP) properties in a model of chronic hyperglycemia before and after challenge with OS by GSH oxidation and tested reversibility of EP remodeling by insulin. Guinea pigs survived for 1 mo following streptoz...

Streptozotocin (STZ) is an antibiotic often used in the treatment of different types of cancers. It is also highly cytotoxic to the pancreatic beta-cells and therefore is commonly used to induce experimental type 1 diabetes in rodents. Resistance towards STZ-induced cytotoxicity in cancer cells has also been reported. Our previous studies have reported organ-specific toxicity and metabolic alte...

This study focuses on the preventive effects of aqueous extract of Cichorium intybus (CIE) on streptozotocin (STZ) induced β-cell damage. Pancreatic β-cells or islet were treated with STZ in presence and absence of Cichorium intybus and the inhibitory effect of it against STZ toxicity were determined in RINm5F (RIN) rat insulinoma cells. Cell viability, Nitric oxide production and Insulin secre...

Ghrelin, an orexigenic peptide produced in the stomach, is increased in streptozotocin (STZ)-induced diabetic (DM) mice. This study clarifies the regulation of ghrelin levels by leptin in STZ-DM mice. STZ-DM mice had higher plasma ghrelin concentrations and greater ghrelin mRNA expression than control mice. Changes in ghrelin levels were dose dependently attenuated by the subcutaneous injection...

To investigate whether ANG II type 1 (AT(1)) receptor blockade could protect kidney mitochondria in streptozotocin-induced Type 1 diabetes, we treated 8-wk-old male Sprague-Dawley rats with a single streptozotocin injection (65 mg/kg ip; STZ group), streptozotocin and drinking water containing either losartan (30 mg.kg(-1).day(-1); STZ+Los group) or amlodipine (3 mg.kg(-1).day(-1); STZ+Amlo gro...

BACKGROUND Streptozotocin-induced diabetes (STZ-D) in rats has been associated with carnitine deficiency, bradycardia and left ventricular enlargement. AIM The purpose of this study was to determine whether oral carnitine supplementation would normalize carnitine levels and cardiac function in STZ-D rats. METHODS Wistar rats (48) were made hyperglycemic by STZ at 26 weeks of age. Same age n...

PURPOSE The aim of this study was to investigate the effect of treadmill exercise on inflammatory response in streptozotocin (STZ)-induced animal model of Alzheimer's disease (AD). METHODS To induce the animal model of AD, Sprague-Dawley rats were injected into intracerebroventricular (ICV) injection with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n = 7), STZ-con...