Disruption of the blood brain barrier plays a significant role in the pathophysiology of subarachnoid haemorrhage. Experimental studies concerning subarachnoid haemorrhage suggested the primary role of free radicals and subsequently lipid peroxidation in the pathogenesis of vasospasm. In this experimental study the role of deferoxamine on blood brain barrier disturbance in vasospasm was evaluat...

DESCRIPTION A lady in her 50s was transferred to the neurosurgical department with reduced conscious level resulting from subarachnoid haemorrhage. The culpable anterior communicating artery aneurysmwas coiled without complication. The following day she remained drowsy and slightly dysphasic, but intimated a sudden alteration in visual acuity in her right eye. On examination, she was unable to ...

Subarachnoid haemorrhage accounts for only 5% of strokes, but occurs at a fairly young age. Sudden headache is the cardinal feature, but patients might not report the mode of onset. CT brain scanning is normal in most patients with sudden headache, but to exclude subarachnoid haemorrhage or other serious disorders, a carefully planned lumbar puncture is also needed. Aneurysms are the cause of s...

Prostaglandins E2, F2 alpha, 6 oxo F1 alpha and thromboxane B2 increased in cisternal CSF following mock subarachnoid haemorrhage in dogs, particularly PGE2 (X25.5). Concentrations were increased also in lumbar CSF of five patients some 8 days after subarachnoid haemorrhage. Subarachnoid haemorrhage did not alter the production of prostaglandins by dog whole cortex or choroid plexuses in vitro,...

Symptomatic hydrocephalus after subarachnoid haemorrhage seems to result both from mechanical obstruction of arachnoid villi and basilar cisterns and from an inflammatory cellular reaction in the villi. Subarachnoid haemorrhage was induced in rabbits using whole blood injected through an implanted intraventricular needle. Control rabbits receiving intraventricular methyl prednisolone acetate bu...

The age and sex specific incidence rates for cerebral infarction, primary intracerebral haemorrhage and subarachnoid haemorrhage in a population of approximately 105,000 are presented. Over four years 675 patients with a first-ever stroke were registered with the Oxfordshire Community Stroke Project. The pathological diagnosis was confirmed by computerised tomography (CT) scan, necropsy or lumb...

controlled trial, they are able to state that for ruptured aneurysms of the inte carotid artery at or near the origin of the posterior communicating vessel, c ligation in the neck produces results far superior to conservative treatment, proVr^j1e that the patients are not unconscious or dying of an intra-cranial haematoma. trial is still proceeding and it is anticipated that further pronounceme...

A case of spinal subarachnoid haemorrhage with progressive spinal cord compression and without any evidence of meningism is described. Spinal block was demonstrated by myelography and computerized tomography and surgical decompression of the subarachnoid blood clot resulted in almost complete recovery. A diagnosis of spinal subarachnoid haemorrhage should be considered in any patient who presen...