The wound healing process is major cause of glaucoma surgery failure and enhances the incapability controlling IOP. This aim study was to evaluate angiogenesis effect Bevacizumab injection on amount density blood vessels in rabbit model after trabeculectomy. It a true experimental using 16 eyes New Zealand White Rabbit (Oryctolagus cuniculus) that divided into two groups. control group treated ...

PURPOSE To study the ultrastructural changes in ciliary body epithelium of the rabbit eye after subconjunctival injections of mitomycin C. METHODS One eye of six New Zealand white rabbits was given a subconjunctival injection at the 12-o'clock position with 0.005, 0.02, 0.08, 0.1, 0.12, or 0.16 mg mitomycin C. The fellow eye was given a subconjunctival injection of balanced salt solution. Two...

PURPOSE To investigate the immediate effect of intravitreal injection of bevacizumab on intraocular pressure (IOP). METHODS This was a prospective and nonrandomized study. A total of 291 eyes with macular edema or active choroidal neovascularization were submitted to a single 1.25 mg (0.05 mL) bevacizumab intravitreal injection. Intraocular pressure was measured with an Icare(®) tonometer imm...

PURPOSE To quantify fibrin degradation products after topical and subconjunctival administration of recombinant tissue plasminogen activator in rabbits. METHODS Fibrin formation was induced in the anterior chamber in 25 rabbits. Subsequently, five rabbits received an injection of r-TPA (positive control) in the anterior chamber, another 10 received a subconjunctival injection of r-TPA, and th...

Subconjunctival gentamicin was identified as the cause of conjunctival chemosis and capillary closure in a recent study conducted in this department. The gentamicin preparation used in the study contained preservatives. The current prospective study was set up to investigate the role of preservatives in the conjunctival toxicity of subconjunctival gentamicin. Seventy five patients undergoing ca...

PURPOSE To evaluate the effectiveness of subconjunctival anesthesia as compared to retrobulbar anesthesia for pain control during manual small-incision cataract surgery (MSICS) performed by third-year residents. DESIGN A randomized, controlled trial. PATIENTS AND METHODS A total of 150 patients undergoing routine cataract surgery were randomly assigned to receive either subconjunctival anes...

PURPOSE Bucillamine is an antirheumatic drug with antiangiogenic properties that is currently used in clinical practice. Because bucillamine inhibits the production of VEGF, it is possible that this drug may inhibit choroidal neovascularization (CNV). Thus, the effect of bucillamine on the eyes of rats with experimental CNV was investigated in vivo by subconjunctival injection or oral intake. ...

PURPOSE To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or surgical enhancements. METHODS This randomized, double-blind, prospective study enrolled 180 patients (360 eyes) in a contralateral eye comparison of topical dilute brimonidine, naphazol...

The ocular penetration, elimination, and toxicity of equidose cytosine arabinoside (Ara-C) (37.5 mg/kg) following subconjunctival versus intravenous injection were compared in rabbits. Drug levels were measured at 0.5, 1, 2, 4, 8, and 12 hours in serum, urine, and ocular compartments. Following subconjunctival administration, the peak concentration of Ara-C in the anterior chamber was 15 times ...