Although histological assessment can assist in many dermatological diagnoses, there has been a recent trend to add imaging modalities improve diagnostic accuracy. Ultrasound uses large array of frequencies that correspond various depths the skin: subcutaneous layer be viewed with high resolution. Subcutaneous nodules, deep-seated lesions deep dermis and layers, are attractive targets for ultras...

Sir, We describe here a rare case of subcutaneous sarcoidosis with perineurial granulomas. A 70-year-old woman was referred to a neurologist in our hospital because of mixed paralysis of the limbs. A chest radiograph revealed bilateral hilar lymphadenopathy. The results of the electrophysiological tests revealed polyneuropathy. The tuberculin test was negative, following a previous positive res...

Systemic SarcoidosisWith Unique Vulvar Involvement Sarcoidosis is a complex, multisystem disease with an unclear cause.1 Research suggests that the pathogeneticmechanism of sarcoidosis is dysregulation of the immune system in individuals with a genetic predisposition who are subsequently exposed to inciting environmental agents.2 Cutaneous sarcoidosis is often one of the earliest clinical signs...

Sarcoidosis is a disease which still has uncertain etiology. Possible environmental causes are cited in the literature, like organic and inorganic particles and infectious agents. Recent studies have demonstrated the occurrence of sarcoidosis in patients with chronic C hepatitis; however, this association remains without statistical or causal evidence. In this report a case of sarcoidosis assoc...

In this issue of the European Respiratory Journal, JUDSON et al. [1] report the results of a large clinical trial involving two new potential therapies in sarcoidosis, a subcutaneous anti-tumour necrosis factor (TNF) agent, golimumab, and a novel anti-p40 (a component of both interleukin (IL)-12 and IL-23) agent, ustekinumab. The rationale for the use of anti-TNF agents in sarcoidosis is compel...