BACKGROUND A combination of mifepristone and misoprostol provides an effective method of medical abortion for early pregnancy. A new route of administration of misoprostol, the sublingual route, was investigated in this study. METHODS One hundred women who requested legal termination of pregnancy up to 63 days were given 200 mg of oral mifepristone followed 48 h later by 800 microg (4 x 200 m...

BACKGROUND The induction of full-term labour in women with a live fetus remains a major challenge in modern obstetrics. OBJECTIVES To determine, using the best level of evidence available, the efficacy and safety of sublingual administration of misoprostol compared with vaginal misoprostol in the third trimester of pregnancy for the induction of labour, according to initial doses, in women wi...

Background: To identify an effective misoprostol-only regime for the termination of second trimester pregnancy. Objectives: To compare the efficacy, safety and acceptability of sublingual and vaginal misoprostol for second trimester pregnancy termination. Methods: In a prospective randomized comparative study, over 138 pregnant women at 13 20 weeks (91 140 days) of gestation requiring medical a...

Aim: To compare the sublingual and vaginal routes of misoprostol in termination of first trimester missed abortion. Methodology: The study was carried out in the Obstetrics & Gynecology unit-II of Bahawal Victoria Hospital Bahawalpur, Pakistan, having yearly turnover > 3000 indoor patients. Results: In vaginal misoprostol group 66.7% cases completely aborted while in sublingual group 73.3% expe...

objective: in this study efficacy of sub lingual misoprostol was examined in comparison to oxytocin (i.v.) for inducing of labor in term pregnancy. materials and methods: seventy patients were allocated by blocked randomization to groups a (n=35, sub lingual misoprostol 25 μg four hourly to maximum of 5 doses) and b (n=35, continuous oxytocin infusion). results: delivery active phase and total ...

BACKGROUND Shivering and fever are common side effects of misoprostol. An unexpectedly high rate of fever above 40°C was documented among Ecuadorian women given treatment with 800mcg of sublingual misoprostol to manage postpartum hemorrhage (PPH) (36%). Much lower rates have been reported elsewhere (0-9%). METHODS From February to July 2010, an open-label pilot study was conducted in Quito, E...

BACKGROUND The pharmacokinetic parameters of four different routes of administration of a single dose of 400 microg of misoprostol were studied. METHODS A total of 40 women undergoing termination of pregnancy by suction evacuation was randomized by computer model to receive 400 microg of misoprostol by one of four routes: (i) sublingual (ii) oral (iii) vaginal and (iv) vaginal with addition o...

Misoprostol is a synthetic prostaglandin E(1) analogue that is commonly used for medical abortion. It can be given orally, vaginally and sublingually. A pharmacokinetic study has shown that sublingual misoprostol has the shortest onset of action, the highest peak concentration and the greatest bioavailability among the three routes of administration. Earlier clinical trials have shown that vagi...

background: in developing countries it is important to the exploration of available and safe regimens for medical abortion. the present study was designed to assess the effect of letrozole compared to placebo pretreatment followed by sublingual misoprostol for therapeutic abortion in eligible women with gestational age less than 17 weeks. materials and methods: in this randomized control trail,...