[D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP) was identified out of a panel of novel SP analogues as the most potent inhibitor of small cell lung cancer (SCLC) cell growth. This analogue inhibited proliferation of H-510 and H-69 SCLC cells in liquid culture and in semisolid media (IC50, 5 microM). Colony formation stimulated by multiple neuropeptides, including vasopressin and bradykinin, was also ...

The aim of the present study was to investigate the endothelial function in human mesenteric arteries with specific reference to defining the role of endothelium-derived nitric oxide (EDNO) and the endothelium-derived hyperpolarizing factor (EDHF). Isolated segments of small human mesenteric arteries (225-450 microm inner diameter) were mounted in organ baths for recording isometric tension. In...

To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and without the addition of either guar, pectin, gum tragacanth, methylcellulose, wheat bran, or cholestyramine equivalent to 12 g fibre. The addition of each substance significantly reduced blood glucose ...

previous studies have shown that electrical stimulation (es) increases blood flow, but the exact mechanisms are not clear. the present study was designed to clarify some of the underlying mechanisms involved in this phenomenon. white adult rabbits lt.-6 months old were used. animals were anesthetized by sodium pentobarbital (40 mg/kg, iv) and skin blood flow in the thoracic back was recorded us...

The aim of this study was to evaluate the influence of selected neuropeptides on itching in psoriatic individuals. Fifty-nine patients (43 pruritic and 16 non-pruritic) with psoriasis were included in the study. The severity of psoriasis, measured using the Psoriasis Area and Severity Index scale, ranged between 2 and 43.7 points. The intensity of pruritus was evaluated using a Visual Analogue ...

BACKGROUND AND AIMS Patterns of brain activation have demonstrated promise as prognostic indicators in substance dependent individuals (SDIs) but have not yet been explored in SDIs typical of community-based treatment settings. DESIGN Prospective clinical outcome design, evaluating baseline functional magnetic resonance imaging data from the Balloon Analogue Risk Task (BART) as a predictor of...

it has been well established that the secretions of thyroid hormones and growth hormone (gh) isunder the regulation of different neurotransmitters. the goal of this study was to determine whethersubstance-p, as a neurotransmitter, regulates the mean plasma concentrations of thyroxin (t4),triiodothyronine (t3), gh, milk amount and constituents in sanan goats. nine sanan goats were randomlydivide...

Abstract Introduction We sought out to evaluate the effects of oxycodone hydrochloride injection on laparoscopic cholecystectomy (LC), substance P, 5-hydroxytryptamine (5-HT), and patient-controlled intravenous analgesia (PCIA). Materials Methods A total 120 eligible patients were randomly divided into an observation group (n=60) control (n=60). Oxycodone (0.07 mg/kg) fentanyl (0.7 μg/kg) intra...