A Mathematical Model of Anaerobic Digestion with Syntrophic Relationship, Substrate Inhibition, and Distinct Removal Rates

In the direction of reductive condensation of alpha-ketoglutarate and lysine, saccharopine dehydrogenase (N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (lysine-forming) is inhibited by high concentrations of alpha-ketoglutarate and lysine, but not by NADH. NAD+ and saccharopine show no substrate inhibition in the reverse direction. Substrate inhibition by alpha-ketoglutarate and lysine is linear...

Observations with acetylcholinesterase can be well explained by postulating that the active site contains two subsites: one, an anionic site which binds and orients substituted ammonium ions, and the other, an esteratic site where the hydrolytic process occurs and which contains a basic group which is acetylated and deacetylated during the process (4, 5). The formation of an acetyl enzyme sugge...

in order to determine the best growing media for gerbera jamesonii under alkaline conditions, a factorial experiment was conducted with two factors, namely: (i) growing medium, and (ii) concentrations of bicarbonate (nahco3) in nutrient solution. results showed that increasing the concentration of nahco3 from 0 to 40 mm in nutrient solution significantly decreased plant growth, maximal quantum ...

Substrate inhibition is a characteristic feature of many cytosolic sulfotransferases. The differences between the complex structures of SULT2A1/DHEA and SULT2A1/PAP or SULT2A1/ADT (Protein Data Bank codes are 1J99, 1EFH, and 1OV4, respectively) have enabled us to elucidate the specific amino acids responsible for substrate inhibition. Based on the structural analyses, substitution of the smalle...

Inhibition of enzyme activity by high concentrations of substrate and/or cofactor is a general phenomenon demonstrated in many enzymes, including aldehyde dehydrogenases. Here we show that the uncharacterized protein BetB (SA2613) from Staphylococcus aureus is a highly specific betaine aldehyde dehydrogenase, which exhibits substrate inhibition at concentrations of betaine aldehyde as low as 0....

Alternative to the use of fossil fuels are biofuels (e.g., bioethanol, biodiesel and biogas), which more environmentally friendly can be produced from different renewable resources. In this investigation, bioethanol production raw sugar beet cossettes (semi-solid substrate) by yeast Saccharomyces cerevisiae in a horizontal rotating tubular bioreactor (HRTB) was studied. Obtained results show th...