AIM Anthracycline-induced cardiotoxicity is (partly) mediated by free radical overload. A randomized study was performed in breast cancer patients to investigate whether free radical scavenger super oxide dismutase (SOD) protects against anthracycline-induced cardiotoxicity as measured by changes in echo, electrocardiography and an array of biomarkers. METHOD AND RESULTS Eighty female, chemot...

To study the influence of season on oxidative status of buffalo semen and their association with semen characteristics and seminal plasma proteins, ejaculates were collected twice a week in winter, summer and rainy seasons from six adult Bhadawari buffalo bulls. The neat semen was analyzed for semen characteristics immediately after collection and oxidative status viz. lipid peroxidation (LPO),...

Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptasepolymerase chain reaction was used to determine the levels of ...

OBJECTIVE To study the focal cerebral ischemia/reperfusion (I/R) injury induced by a middle cerebral artery occlusion (MCAO), and the effects of Yulangsan (YLS) polysaccharide on this injury. METHODS This study took place in the Pharmacology Research Laboratory at Guangxi Medical University, China, between March and May 2007. Two hundred and forty rats were randomly divided into I/R group, sh...

We tested the hypothesis that the mitochondrial form of superoxide dismutase [manganese superoxide dismutase (Mn-SOD)] protects the cerebral vasculature. Basilar arteries (baseline diameter approximately 140 microm) from mice were isolated, cannulated, and pressurized to measure vessel diameter. In arteries from C57BL/6 mice preconstricted with U-46619, acetylcholine (ACh; an endothelium-depend...

This study was conducted to investigate the effect of different levels of savory (Satureja hortensis) powder and its essential oil on performance and antioxidant status of broiler chickens under heat stress (34±2 ˚C for 8 hours per day). A total of 336 one-day-old male broiler chicks (Ross-308) were divided into 6 treatments and 4 replications (14 birds per replicate). Experimental diets were a...

The aim of the present study was to look into the possible protective effects of glycyrrhizic acid (GA) against isoproterenol-induced acute myocardial infarction in Sprague-Dawley rats. The effect of three doses of glycyrrhizic acid in response to isoproterenol (ISO)-induced changes in 8-isoprostane, lipid hydroperoxides, super oxide dismutase and total glutathione were evaluated. Male Sprague-...

BACKGROUND/AIM Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes ...

Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. The ischemia infarction model was established in rats. Left ventricular functi...

Cadmium (Cd) is considered as phytotoxic in nature, its toxicity on the plant development decrease antioxidative enzymes activities under stress environment. Castor (Ricinus Communis L.) a metal tolerant and ability to survive highly polluted soils. exhibited high level of Cd soil buildup antioxidants i.e., super oxide dismutase (SOD), peroxidase (POD) malondialdehyde (MAD) top ground parts str...