In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and croscarmellose sodium in the different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. T...

In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the...

Orally disintegrating tablets of Furosemide were prepared, evaluated and the comparison action different concentrations disintegrants on disintegration dissolution studied. Direct compression method was used to prepare orally containing 20 mg Furosemide. The formulation conducted using crospovidone, croscarmellose sodium starch glycolate as superdisintegrants their interactions with also FTIR. ...

Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study two different methods direct compression and sublimation in formulation of mouth dissolving tablets of clozapine. Total four formulations using various superdisintegrants and subliming...

In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate...

Amaç: Farklı üç süper dağıtıcının, ki bunlar; kroskarmeloz sodyum, sodyum nişasta glikolat ve Indion 414, doğrudan basım ile hazırlanan salbutamol sülfat oral dağılan tabletlerinde (ODT) hızlı dağıtma etkisi için ayrı ayrı veya ikili kombinasyonlarında çalışıldı. Gereç ve Yöntemler: ODT’ler farklı üç süper dağıtıcı kombinasyonunda; A, B ve C, hazırlandı. Herbir kombinasyonda süperdağıtıcıların ...

Since orally disintegrating tablets (ODTs) of tramadol hydrochloride are not available in the market, so an attempt has been taken to formulate and evaluate ODT preparation hydrochloride. In this present work, direct compression was technique used for preparing using superdisintegrants like croscarmellose sodium, sodium starch glycolate crospovidone at different concentrations. Prepared formula...

Orodispersible tablets (ODT) of levocetirizine was prepared using natural polysaccharides ipomoea batatas starch, amorphophallus campanulatus starch and their modified form by direct compression method and evaluated for their superdisintegrant activity. Levocetirizine dihydrochloride was used as a model drug. The prepared formulations were compared with synthetic superdisintegrants such as cros...

Introduction: Orodispersible films (ODF) is a thin strip that mostly transparent, biodegradable and it has hydrophilic polymers disintegrate dissolves immediately when getting in contact with saliva. Different disintegrants play crucial role film properties such as organoleptic properties, thickness, particular disintegration time of the film. The main reason for development oral their prominen...