Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copperand zinc-containing Superoxide dismutase (CuZn Superoxide dismutase) and manganese-contain ing Superoxide dismutase (Mn Superoxide dismutase) were specifically assayed in human malignant tumors and for com parison in human tissues. The tumors possessed les...

Among all microRNAs (miRNAs) in 12 plant species investigated in this study, only miR398 targeted the copper chaperone for superoxide dismutase (CCS). The nucleotide sequences of miRNA binding sites were located in the mRNA protein-coding sequence (CDS) and were highly homologous. These binding sites in CCS mRNA encoded a conservative GDLGTL hexapeptide. The binding sites for miR398 in the CDS ...

Superoxide dismutase is antioxidant enzyme responsible for the quenching of superoxide radicals which are released during the chemical reactions of the various metabolic pathways. It is a non-heme protein. Different iso-enzymes of superoxide dismutase are described. The mitochondrial enzyme is manganese dependent, cytoplasmic enzyme is copper-zinc dependent. These enzymes are evenly and ubiquit...

The vascular endothelium is important for the early and late effects observed in lethally irradiated tissue and organs. We examined the effects of exogenously added superoxide dismutase on cell survival and angiogenesis in lethally irradiated human primary umbilical vein endothelial cells. Cell survival was significantly improved in superoxide dismutase-treated cells; the addition of superoxide...

three levels of lysine (90, 100 and 110% of ross requirement) and of pyridoxine (3, 6 and 9 mg kg-1) were used in a 3 × 3 factorial experiment to investigate the growth and blood antioxidant ability of broilers under high ambient temperature. none of the dietary supplements affected the weight gain during the starter and grower periods. although no significant differences were detected between ...

Acute cerebral ischemia increases the generation of free radicals, causing cell damage, and theoretically may decrease the activity of the scavenging enzyme superoxide dismutase. To investigate the role of superoxide dismutase in cerebral ischemia, we used a model of middle cerebral artery occlusion in rats. In this model an infarct is produced in the pyriform and frontoparietal cortices, exten...

The activity of superoxide dismutase isoenzymes was determined in knee joint synovial fluid from 21 patients with rheumatoid arthritis, nine patients with reactive arthritides, and from 17 patients before arthroscopy or arthrotomy for suspected meniscal or ligament injury (controls). Extracellular superoxide dismutase was the major isoenzyme and accounted for about 80% of the total superoxide d...

Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that previously has been demonstrated to be the major superoxide dismutase of human extracellular fluids. The occurrence of this enzyme in various human tissues that were removed from two accidental death victims and in 19 different human cultured cell lines was determined. All investigated tissues were found to c...

Photosynthetic oxygen reduction by isolated chloroplast lamellar systems has been studied with the aid of superoxide dismutase. Two mechanisms of oxygen reduction by illuminated chloroplast lamellar systems can be differentiated: 1. In the presence of low potential electron acceptors like AQ or MV the superoxide free radical ion is the product of autooxidation of the reduced acceptor. Addition ...