Serotonin 1A (5-HT1A) receptors have been mechanistically implicated in micturition control, and there has been a need for an appropriate biomarker surrogating the potency of a provisional drug acting on this receptor system for developing a new therapeutic approach to overactive bladder (OAB). Here, we analyzed the occupancy of 5-HT1A receptors in living Sprague-Dawley rat brains by a novel ca...

| Many applications in teleoperation and virtual reality call for the implementation of e ective means of displaying to the human operator information on the softness and other mechanical properties of objects being touched. The ability of humans to detect softness of di erent objects by tactual exploration is intimately related to both kinesthetic and cutaneous perception, and haptic displays ...

In global optimization, when the evaluation of the target function is costly, the usual strategy is to learn a surrogate model for the target function and replace the initial optimization by the optimization of the model. Gaussian processes have been widely used since they provide an elegant way to model the fitness and to deal with the explorationexploitation trade-off in a principled way. Sev...

Neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations and needs immediate empirical antimicrobial therapy. Choosing an appropriate antibiotic regimen covering the most probable pathogens is an important issue. In this study we compared the effectiveness of ceftizoxime and amikacin in the treatment of neonatal sepsis both in combination with ampicillin...

Diastolic dysfunction of the heart is correlated with cardiac mortality. Serum cystatin C (CysC) is an endogenous marker of kidney function. It is not clear whether serum CysC is associated with diastolic dysfunction in patients with varying cardiac conditions with concomitant diastolic abnormalities and preserved ejection fraction (EF). The authors measured serum CysC levels in patients with c...