Editorial WHO downgraded oseltamivir (Tamiflu) New Products Hypnotic (sleeping pill), suvorexant (brand name Belsomra) A substance that causes narcolepsy and cataplexy Teriparatide More harm than benefit: Review Insomnia, Optimal Sleep Duration and Harm of Sleeping pills Pneumonia caused by proton pump inhibitors (PPI) (1) meta-analysis (2) Critical appraisal of a study CONTENTS (December 2017,...

Background Nocturnal eating behavior in patients with sleep-related disorder (SRED) is difficult to control and can become chronic, causing weight gain psychological distress. Here, we report a case of SRED comorbid major depressive successfully treated by switching from brotizolam suvorexant, that is, benzodiazepine an orexin receptor antagonist. Case Presentation A 25-year-old woman complaine...

Aim Although suvorexant and lemborexant, which have orexin receptor antagonist activity, are used as sleep medications in Japan, no report has directly compared their efficacy safety. This study the safety of drugs. Methods retrospective cohort included patients who presented to Outpatient Department Psychiatry at Tottori University Hospital between December 1, 2020, 31, 2021. Information was o...

Several agents are known to improve sleep induction and/or maintenance in patients with insomnia disorder. These include the benzodiazepine (BZD) and non-BZD receptor allosteric modulators, the melatonin receptor agonist ramelteon, low-dose doxepin, and suvorexant. One of the drawbacks of the BZDs is their known reduction in both N3 sleep [also known as slow wave sleep or delta sleep and charac...

Orexin (hypocretin) neuropeptides have, among others, been implicated in arousal/sleep control, and antagonizing the orexin signaling pathway has been previously demonstrated to promote sleep in animals and humans. This mechanism opens up a new therapeutic approach to curb excessive wakefulness in insomnia disorder rather than to promote sleep-related signaling. Here we describe the preclinical...