B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly use in chemotherapy.Although,colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully und...

Isolated rat liver mitochondria undergo swelling in the presence of certain substances of physiological occurrence which include inorganic phosphate (I), Ca*, (2), L-thyroxine (2, 3), reduced glutathione (4)) and an isooctane-soluble uncoupling agent formed enzymatically in mitochondria, designated U factor (5). Such swelling, with the exception of that brought about by glutathione (4), has bee...

Weathered crust elution-deposited rare earth ores are key strategic resources and the main source of medium heavy earths. This paper summarizes development leaching technology ores, compares advantages disadvantages three generations technology, introduces improved heap new leaching–extraction integration enhanced leaching, focusing on weathered ores. In this paper, agents is expounded, researc...

Triethyltin induces swelling of isolated rat liver mitochondria suspended in sucrose or KC1 media. This effect is not seen with brain mitochondria. Triethyltin swelling is only minimally reduced by EDTA or amytal but is prevented by 2 :Cdinitrophenol, cyanide or salicylate. The addition of adenosine trior diphosphate causes reversal of the swelling; this effect is potentiated by Mn2+ but not by...

In this article, we synthesize a novel chitosan -based superabsorbent hydrogel via graft copolymerization of mixtures acrylic acid (AA) and N-vinyl pyrollidon onto chitosan backbones. The polymerization reaction was carried out in an aqueous medium and in the presence of ammonium persulfate (APS) as an initiator and N,N'-methylene bisacrylamide (MBA) as a crosslinker.The hydrogel structures wer...

Streptolysins S and 0 from hemolytic streptococci were found to induce mitochondrial swelling and the release of malic dehydrogenase from mitochondria; no other streptococcal products were as active. Mg ++, cyanide, dinitrophenol, bovine serum albumin, and antimycin all inhibited streptolysin-induced mitochondrial swelling; only the latter two agents prevented release of malic dehydrogenase fro...

A novel two-step release system for the traditional Chinese medicine compound Danshen was developed by combining an effervescent osmotic pump tablet (EOPT) and a pulsed-released tablet (PT) of compound Danshen into one hard capsule. The EOPT of Danshen was prepared with sodium chloride, mannitol, hydroxypropylmethylcellulose (HPMC), and sodium bicarbonate as osmotic agents. The osmotic pressure...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...

Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflam...