Non-melanoma skin cancers (NMSCs), which include basal cell carcinoma (BCC), squamous (SCC), and actinic keratosis (AK), are the most common cancer diseases in Caucasian race. If diagnosed late improperly treated, BCC SCC can become locally advanced metastasize. Malignant melanoma (MM) is less frequent but more lethal than NMSC. Given individual social burdens of cancers, performing an adequate...

Mutations in the BRCA1 and BRCA2 genes are known risk factors drivers of breast ovarian cancers. So far, few studies have been focused on understanding differences transcriptome functional landscapes associated with disease (breast vs. cancers), gene (BRCA1 BRCA2), mutation type (germline somatic). In this study, we were aimed at systemic evaluation association germline somatic mutations expres...

background: previous studies indicate a high incidence of digestive cancers along southern parts of caspian sea including ma­zandaran province. the present study was conducted to further investigate time to occurrence, age distribution and pos­sible risks associated with the incidence time of digestive cancers in the above regions. methods: for this purpose the data of digestive cancer incidenc...

conclusions most patients are referred for restaging and demonstrate evidence of regional or distant metastasis with significant value for further treatment planning. providing insurance coverage and familiarizing referring physicians about appropriate indications of this relatively new diagnostic modality will be to the best interest of head and neck cancer patients in long term. methods we re...

Esophageal squamous cell carcinoma is an aggressive malignancy with histologic variability depending on where in the world it diagnosed, most of these cancers occurring China and other parts Asia. Previous studies cytotoxic chemotherapy combinations led to a plateau median overall survival approximately 10 12 months, as well need for more effective treatment options. Cytotoxic served control ar...

xx Signed statement xxv Acknowledgements xxvi

The purpose of this report is to present the findings in a case of squamous cell carcinoma (SCC) of the conjunctiva which was the initial sign of systemic cancers. A 94-year-old woman without known systemic diseases developed a mass in her right conjunctiva. She was referred to our hospital 5 months after the onset. She was diagnosed with conjunctival SCC by biopsy. Systemic CT before the surge...

U.S. SEER (Surveillance Epidemiology and End Results) data for age-adjusted mortality rates for all cancers combined for all races show only a modest overall 13% decline over the past 35 years. Moreover, the greatest contributor to cancer mortality is treatment-resistant metastatic disease. The accepted therapeutic paradigm for the past half-century for the treatment of advanced cancers has inv...