Corticosteroids are being rn;;ed in different ophthalmic disorder as anti-inflamatory agent.  A.C.T.H. stimulated the supra renal glands and causes an increase steroid concentration of the blood. Corticosteroids can be used as anti­inflamatory agent locally ar.d systemically.  The new corticom,teroids like prednison, dex­xametason and prednisolon are more effective ( 5 to 10 times) than the o...

The effectiveness of, and increasing indications for, the use of inhaled corticosteroids in asthma of varying severity prompts important questions to be raised relating to safety and the possibility of adverse systemic steroid effects. This concern is not new and has already resulted in guidelines on the use of spacer devices for high dose inhaled steroids in order to decrease systemic absorpti...

BACKGROUND Asthmatic patients taking low to moderate doses of inhaled topical corticosteroids have been shown to have lower bone density than those taking bronchodilators only. There is little information on bone density in asthmatic patients taking high dose inhaled corticosteroids. METHODS Bone mass was studied in three age matched groups of asthmatic patients. These comprised: 17 asthmatic...

BACKGROUND Central serous chorioretinopathy is a disorder often related to systemic corticosteroids, drugs commonly used in rheumatologists' clinical practice. Central serous chorioretinopathy prognosis is generally good but in some cases, it may lead to substantial loss of vision resulting in an important functional limitation for patients. It is very important to distinguish this pathology fr...

Respiratory exposure to allergen induces T cell tolerance and protection against the development of airway hyperactivity in animal models of asthma. Whereas systemic administration of dexamethasone during the delivery of respiratory Ag has been suggested to prevent the development of mucosal tolerance, the effects of local administration of corticosteroids, first-line treatment for patients wit...

BACKGROUND Determining whether systemic corticosteroids impair wound healing is a clinically relevant topic that has important management implications. METHODS We reviewed literature on the effects of corticosteroids on wound healing from animal and human studies searching MEDLINE from 1949 to 2011. RESULTS Some animal studies show a 30% reduction in wound tensile strength with perioperativ...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a chronic and progressive disease that affects an estimated 10% of the world's population over the age of 40 years. Worldwide, COPD ranks in the top ten for causes of disability and death. Given the significant impact of this disease, it is important to note that acute exacerbations of COPD (AECOPD) are by far the most costly and devast...

Background/objective: Despite the present routine treatment of septic arthritis with antibacterial agents, articular damage is persistent and frequently leads to loss of joint function.  The aim of this study was to assess the effect of intra-articular corticosteroids added to systemic antibiotics in the treatment of experimental staphylococcal knee joint infection in rabbits. Methods: Thirty r...

The treatment of ARS primarily involves symptomatic control with intranasal corticosteroids and nasal saline irrigation; antibiotics should be reserved for the patients who are believed to have bacterial rhinosinusitis. Treating CRS effectively involves using intranasal corticosteroids and irrigation, systemic corticosteroids, and potentially systemic antibiotics. Biologics (mAbs) have shown be...

BACKGROUND The clinical features of drug-induced hypersensitivity syndrome (DIHS) or drug rash with eosinophilia and systemic symptoms (DRESS) syndrome are complicated, and the incidence of this condition is very low. OBJECTIVE To evaluate the clinical course of DIHS/DRESS and identify effective treatment options. METHODS This study was a retrospective analysis of prospectively collected cl...