objective(s): vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. structural study and finding the active site of vinblastine are the targets of this research.   materials and methods: vinblastine was optimized in vacuum and then in different solvents by density functional theory (dft) method. nuclear magnetic resonance (nmr) ...

in this study, we present the work on the physicochemical interaction between the anti-cancer alkaloidberberine (brb) and dna with the purpose of designing drugs that interact more with dna. molecularmodeling on the complex formed between berberine and dna presented that this complex was undeniablyfully able of participating in the formation of a stable intercalation site. besides, the molecula...

in this research, we report the results of dft calculations using xc-hybrid functional, b3lyp and employ nbo interpretation to investigate the stereoelectronic effects. electrostatic and steric impacts on the conformational properties of 1,2-difluorodiazene (1), 1,2-dichlorodiazene (2) and 1,2-dibromodiazene (3) are also studied. factors determining the thermodynamically stable molecular struct...

halliday’s systemic functional linguistics (sfl) has stood the test of time as a model of text analysis. the present literature contains a plethora of studies that while taking the ‘clause’ as a unit of analysis have put into investigation the metafunctions in research articles of a single field of study or those of various fields in comparison. although ‘clause complex’ is another unit of sf a...

language, science and politics go together and learning these genres is to learn a language created for codifying, extending and transmitting scientific and political knowledge. grammatical metaphor is divided into two broad areas: ideational and interpersonal.this paper focuses on the first type i.e. ideational grammatical metaphor (igm), which includes process types and nominalization.  the m...

Within Systemic Functional Linguistics, Grammatical Metaphor (GM) is a meaning-making resource lying at the experiential level that extends the meaning potential through cross-stratal re-mappings between the grammar and the semantics, boiling down, in one of its manifestations to expressing something that should have been a process (verb) in terms of a thing (noun). This study is an attempt at ...

Since the past 10 years, theory of semantic waves has further progressed. This is deeply rooted in knowledge structures, legitimation code theory, and systemic functional linguistics. In addition, can also be applied discourse analysis, language learning, teaching, many other fields.