Drug-induced scleroderma is a rare adverse effect of some chemotherapeutic drugs, such as taxanes and bleomycin. Capecitabine, an oral fluoropyrimidine approved for the treatment of metastatic breast and colon cancer, commonly causes cutaneous side effects including the hand-and-foot syndrome (HFS). Scleroderma-like skin changes associated with HFS associated with capecitabine is rare. However,...

BACKGROUND Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. MAIN OBSERVATIONS We present a case of systemic scleros...

background: scleroderma is a chronic connective tissue disease of unknown etiology. vitamin d and parathyroid hormone (pth) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. klotho, the co-receptor of the fibroblast growth factor 23 (fgf-23), can interfere with calcium and phosphate metabolism. the purpose of this study was to ...

Hospital Physician January 2008 33 S ystemic sclerosis, or scleroderma, is a rare connective tissue disease of unknown etiology. The word scleroderma, derived from the Greek words scleros for hard and derma for skin, refers to the hallmark finding of chronic hardening and thickening of the skin that occurs in this disease. The clinical manifestations of systemic sclerosis range from localized s...

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tiss...