Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycoba...

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematological disease. Modern polychemotherapy protocols allow achieving a 5-year overall survival of 60–90 % in different age groups, however, relapses and refractory forms T-ALL remain incurable. Over the past decades, pathogenesis this variant leukemia has been studied many trials, it found that various signaling pathways ...

dear editor-in-chief a 28 yr male was presented in october 2015 at medicine outpatient department, safdarjung hospital, new delhi- india with generalized weakness, fever and cough for preceding 15 days. clinicoradiologic examination revealed pallor, firm, non-tender splenomegaly measuring 13.7 cm and hepatomegaly (liver span - 16.9 cm). however, no lymphadenopathy was found.

acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. the conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. it has been rarely reported in the literature. in leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. herein, we rep...

Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycoba...

Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease virus-associated tumors. We investigated whether the amount of cfDNA human T-cell leukemia virus type 1 (HTLV-1) correlates with state adult leukemia-lymphoma (ATL). HTLV-1 aggressive ATL was significantly higher than that indolent asymptomatic carriers. Notably, patients lymphoma represe...

: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of non-Hodgkin's (NHL), characterized by poor outcome, accounting approximately for 10%-15% all non-Hodgkin in the western countries, and with higher prevalence Asia. Cyclin D1 immunoreactivity is characteristically seen mantle cell lymphoma. It also observed hairy leukemia, plasma myeloma proportion diffuse large B-cell lymp...

CAR T cell therapy is a promising immunotherapy that can target and eradicate leukemia cells with high specificity. While CD19, CD20, CD22 have shown impressive responses in ALL patients

APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α+ and CD103+ dendritic cells (DCs), in particular, required spontaneous initiation CD8+ priming against solid tumors. In contrast, little is known about that regulate responses hematological malignancies. Using an unbiased approach, we aimed to characterize responsible regu...