OBJECTIVES The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. Quasi-emulsion solvent diffusion was used as a crystal modification method. MATERIALS AND METHODS Corn starch was dissolved in hydrochloric acid at 80°C and then ethanol as a non-solvent was added with lowering temperature u...

Various solvents can be used in the synthesis of the illicit synthetic drug methylenedioxymethamphetamine (MDMA, commonly known as Ecstasy). In the crystallization process, traces of those solvents can be trapped inside crystals; during the following tabletting process, the solvent traces remain present in the tablets. The forensic investigation of tablets for solvents may increase knowledge of...

For increased analgesic effect, new composed tablets containing diclofenac sodium (DIC) with an addition of papaverine hydrochloride (PAP) were prepared to investigate the mechanism of release of the active substances from tablets with different excipients in eight different formulations. To detect the possible interactions between active substances and excipients differential scanning calorime...

In case of Thiocarlidum (1) the thermoanalytical examination showed an endothermic transformation without loss of weight. This occured in samples recrystallized from cold polar solvents and the transformation proved to be non-reversible. The UV and IR spectra of the two samples differed characteristically and X-ray studies showed that the two modifications (in the following aand ßmodifications ...