Wistar rats were given a diet with 8% sodium chloride to induce hypertension and subsequently sacrificed. Glycine max powder was used reduce atenolol’s side effects during the trial. Thirty divided into five groups tested over eight weeks. Rats’ blood pressure (BP) measured tail-cuff NIBP monitor. Biochemical markers like TG, TC, HDL, LDL, VLDL, alanine transferase, aspartate lipid peroxide (LP...

Blockade of the renin-angiotensin system was studied in male Sprague-Dawley rats during long-term inhibition of nitric oxide synthase. Nitro-L-arginine-methyl ester (L-NAME) was placed in the drinking water for 4 weeks (approximately 100 mg/kg per day). Separate groups of rats were coadministered the angiotensin II antagonist A-81988 in the drinking water ranging from approximately 0.001 to 1 m...

Fructose feeding has been widely reported to cause hypertension in rats, as assessed indirectly by tail cuff plethysmography. Because there are potentially significant drawbacks associated with plethysmography, we determined whether blood pressure changes could be detected by long-term monitoring with telemetry in age-matched male Sprague-Dawley rats fed either a normal or high-fructose diet fo...

because microaspiration of contaminated supraglottic secretions past the endotracheal tube cuff is considered to be central in the pathogenesis of pneumonia, improved design of tracheal tubes with new cuff material and shape have reduced the size and number of folds, which together with the addition of suction ports above the cuff to drain pooled subglottic secretions leads to reduced aspiratio...

A study was conducted in albino wistar rats to evaluate the antihypertensive effect of a herbal drug, Lagenaria siceraria in Dexamethasone induced hypertension. Duration of the experiment was 5 days. During the study, aqueous, ethanol, petroleum ether and chloroform extracts of fruits of Lagenaria siceraria were given by orally. The parameter observed was blood pressure. Bloodpressure was measu...

A study was conducted in albino wistar rats to evaluate the antihypertensive effect of a herbal drug, Trichosanthes dioica in Dexamethasone induced hypertension. Duration of the experiment was 5 days. During the study, aqueous, ethanol, petroleum ether and chloroform extracts of fruits of Trichosanthes dioica were given by orally. The parameter observed was blood pressure. Bloodpressure was mea...

Methods of indirectly determining blood pressure in the rat are reviewed and their drawbacks noted. A new method is described which has the advantage of objectivity and provides permanent graphic record of each determination. The end point used is the reappearance of pulsation in the foot distal to a slowly deflating leg cuff. Application of the method is described and its use compared with tai...