Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potential carcinogens. In the current study, the potential DNA damage associated with...

The induced toxicity of three pesticides (alpha-Hexachlorocyclohexane: α-HCH; Parathion methyl:PM; Carbofuran: CN) in single and four possible combination on human keratinocyte cell line have been investigated. There was no significant change in toxicity (cyto and genotoxicity) on cell line exposed by individual pesticides except α-HCH. But, a synergistic effect was observed when we tested mixt...

Biomaterials are engineering products that widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts implantable devices. These materials medicine because they compatible with the organism, not allergic, resistant to physical chemical factors. Hydroxyapatites bioactive calcium phosphate ceramics tissues. To increas...

A series of studies was performed to evaluate the safety of dihydrocapsiate (4-hydroxy-3-methoxybenzyl 8-methylnonanoate; CAS no. 205687-03-2). This study evaluated the potential genotoxicity of this compound using a variety of in vitro and in vivo test systems, including bacterial reverse mutation test, chromosomal aberration test, micronucleus test, gene mutation assay with transgenic rats, a...

Abstract Maleic acid polymer scale inhibitor is a new domestic seawater desalination inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this The LD 50 obtained from test was 6810 9260 mg/kg·BW for male female rats, as well 1/5, 1/10 1/20 were dose test. It showed weight rats with high significantly lower than control group during exposure period ( p &...

Microplastics (MPs) attract global concern due to their ubiquitous existence in aquatic environments. However, the genotoxic effect of MPs on organisms natural environment remains controversial. Therefore, this meta-analysis was conducted by recompiling 44 individual studies from 12 publications determine whether could induce genotoxicity at environmentally relevant concentrations (≤1 mg/L, med...

Oxyclozanide is a salicylanilide derivative anthelmintic drug with well-known effect on parasites that cause infections in humans and animals. In this study, the of oxyclozanide DNA damage hemocytes Galleria mellonella (L.) (Lepidoptera: Pyralidae) larvae, which has been used as model organism many fields, was investigated. Hemolymph collected from last instar larvae (7th instar) reared artific...

Background: Organophosphorus pesticides has been widely used in agriculture fields to control various crop insects and their extensive use pose human life at threat because of their adverse effects on human health. In this study, we checked the effects of GST polymorphism on ameliorative effect of curcumin and carvacrol against DNA damages. Methods: Comet assay was used to assess the DNA dam...

Chlorpyrifos is a most widely used organophosphate insecticide because of its cost effectiveness and degradable nature. However, this pesticide enters and contaminates the environment either by direct application, spray drifts or crop run off and shows adverse effect on the non-targeted organisms. Philosamia ricini (eri silkworm), one of the most exploited, domesticated and commercialized non m...

Nitrites are ubiquitous environmental contaminants present in drinking water and foods. Nitrosamines can be formed endogenously from nitrate and nitrite and secondary amines or may be present in food, tobacco smoke, and drinking water. The major goal of this work was to evaluate the cytotoxic, reactive oxygen species (ROS)-producing and genotoxic effects of nitrite and nitrosamines and the poss...