In our effort to find diagnostic markers and to develop therapeutic approaches for prostate cancer, we have identified an mAb that is capable of binding to a cell surface antigen specifically expressed on both androgen-dependent and androgen-independent prostate cancer cells. Immunohistological studies revealed that this mAb, called F77, stained 112 of 116 primary and 29 of 34 metastatic human ...

A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c selected at five dose concentration levels. It exhibited potent broad-spectrum activity with a GI50 4 nM–37 µM. Cytotoxicity further evaluated prostate, renal, and breast cancer doub...

Prostate cancer is one of the most common cancers and one of the leading causes of cancer-related death among men of all races. Complementary and alternative medicine is also used in the treatment of prostate cancer, thus, screening of natural products represents a promising strategy to develop potential anticancer drugs for prostate treatment. Cryptotanshinone, one of the major tanshinones iso...

cancer is the second leading cause of death in the world. despite advances in the diagnosis and treatment, overall survival of patients still remains poor. hence, there is an urgent need for development of new anticancer agents. considering promising biological activity of 1,3,4-thiadiazole derivatives, in the present study, synthesis and cytotoxicity assessment of new derivatives of this ring ...

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

to determine the normal ranges of serum age-related prostate-specific antigen (psa) level in men from beijing area without cancer.in this cross sectional study, form april 2010 to october 2011, 1611 healthy men undergoing a routine health check-up in our hospital and all men received three examinations including serum psa test, digital rectal ex-amination and transrectal ultrasound. men with an...

Prostate cancer is the most common type of diagnosed in men worldwide and second leading cause death after lung cancer. Testosterone dihydrotestosterone (DHT) have been known to play an essential role prostate Androgen receptor (AR) binding ligand allows homodimerization translocation nucleus, which acts as a transcription factor for androgen-responsive genes such PSA (Prostate-specific antigen...

we assessed the lower urinary tract symptoms (luts) in prostatic cancer patients and investigated the sensitivity and specificity of international prostate symptom score (ipss) in the screening of these patients. a total number of 132 prostatic cancer patients as the case group who were confirmed by the pathologists and 101 noncancerous men as the control group, aged 50 or older, responded to a...

Title: 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models