Traumatic Brain Injury (TBI) in all degrees of injury severity mainly induces deviant cognitive, emotional and behavioral alterations that lead to their respective disorders. This brief overview strives to define the variables that determine the risk of occurrence of these disorders and to describe the common patterns of these disorders and their relevant neuropathogenetic mechanism(s). In addi...

Objective(s): Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-T...

Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...

A major public health problem, traumatic brain injury (TBI) can cause severe neurological impairment. Although autophagy is closely associated with the pathogenesis of TBI, role in deficits unclear. The purpose present study was to investigate molecular mechanisms endoplasmic reticulum (ER) stress‑induced and its detrimental effects on outcomes following TBI. rat model TBI established by contro...

Background: This study aimed to analyze the catabolic phases of patients with traumatic brain injury (TBI) by performing Nitrogen Balance Test (NB Test).Methods: single-centered, retrospective included data from 292 who underwent NB tests 2019 2022 and categorized them as TBI Non-TBI groups. The basic clinical factors (gender, age, initial GCS), critical care (APACHE, SOFA, ICU stay days), outc...

Traumatic brain injury (TBI) is a significant public-health concern. To understand the extent of TBI, it is important to assess the prevalence of TBI in the general population. However, the prevalence of TBI in the general population can be difficult to measure because of differing definitions of TBI, differing TBI severity levels, and underreporting of sport-related TBI. Additionally, prevalen...

OBJECTIVE To examine how pre-traumatic brain injury (TBI) variables and TBI-related characteristics predict post-TBI criminal arrest, using longitudinal data from the Traumatic Brain Injury Model System National Database. SETTINGS Medical hospitals; rehabilitation facilities. PARTICIPANTS Participants with documented TBI and nonmissing Traumatic Brain Injury Model System data, resulting in ...

traumatic brain injury (tbi) is one of the most common neurological diseases with no definite treatment. erythropoietin (epo) and progesterone (prog) have been shown to have neuroprotective effects in different types of experimental brain injury models. this study was designed to determine the effect of epo, prog and combination of epo/prog on neurological outcome after traumatic brain injury. ...