The administration of soluble myelin proteins is an effective way of down-regulating the inflammation in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. To shed more light on the mechanism of this antigen-specific therapy, we determined the effect of the intraperitoneal (i.p.) injection of soluble myelin basic protein (...

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BACKGROUND & OBJECTIVE Activation of T cells is mediated through two critical signals provided by activated macrophages. The first signal is triggered when T cell receptor (TCR) binds to the major histocompatibility antigen (MHC/Ag) complex. The second signal is the interaction of co-stimulatory molecules with their respective ligands on T cells for their activation and proliferation. We undert...

Purpose: We have previously identified a CD2 mediated, interleukin-12 dependent signalingpathway that inhibits activation induced cell death in mitogen stimulated human -T cells,permitting the large-scale expansion of these cells. Herein we report the innate antitumoractivity of expanded human V 9V 2 -T cells against human prostate cancer cells.Materials and Methods: Apoptosis r...

CD80 and CD86 – B7 costimulatory ligands expressed by antigen presenting cells. They interact with coreceptors CD28 and CTLA4 on Tcells and are necessary, but not sufficient for T-cell activation. MHC class II (major histocompatibility complex class II molecules) – These molecules typically acquire autoantigen epitopes in endosomes and antigen processing compartments of antigen presenting cells...

Rasmussen’s encephalitis (RE) is neurological disorder of childhood characterized by uni-hemispheric inflammation, intractable focal epilepsy and progressive cognitive and neurological deficits. Currently, hemispherectomy is the only effective method to control the seizures associated with RE. Although this disease has been heavily investigated, the pathogenesis of RE with unilateral cortex atr...