The thalidomide catastrophe in 1959-1962 has given great impetus to the basic research interests in the adverse effects of various insults on germ cells, embryos, fetuses, and immature postnatal individuals. It has called further attention to behavioral ability to learn or respond appropriately to a changing environment in the offspring that are prenatally exposed to various insults, even thoug...

have been incorporated into this edition, and a new section on prenatal diagnosis appears in the chapter on teratology. Other additions include a nice outline of embryonic stages 123 on the inside cover, with corresponding drawings of the embryo and fetus, a list of abbreviations used in the figures and a table of earlier terms and their more contemporary counterparts. The text treats the subje...

The purpose of this conference was to reevaluate the need for and use of in vitro teratology assays; to examine the validation process for in vitro tests; and to discuss progress in the validation of in vitro teratology screens. Participants enthusiastically supported further development of short-term in vivo and in vitro systems both as prescreens for developmental toxicity and as experimental...