Proteins are polymers made up of amino acids linked via their alpha amino and carboxyl groups respectively, creating planar interconnecting amide bonds. The order of the twenty naturally occurring amino acids in the polymer is called the amino acid sequence or primary structure, and all other levels of protein structure, including secondary (alpha helix, pleated sheet or random coil), tertiary ...

The substrate specificity of cholylglycine hydrolase has been investigated using bile acid conjugates with modifications in the steroid ring system, the side chain, or the amino acid moiety. Epimerization at C-3 and C-7 did not affect the activity of the enzyme while oxidation of the three nuclear hydroxyl groups reduced the affinity of the enzyme toward the substrate. Elongation of the side ch...

The crystal structure of the title compound, C(27)H(45)N(3), has been determined as part of our investigation into the hydro-phobic modification of amino-glycoside anti-biotics. The isopropyl group showed disorder for the tertiary carbon (equal occupancies), with high thermal motion for the peripheral atoms of the isopropyl and azide groups also apparent in the structure. The axial disposition ...

1:1 salt of Disopyramide (DPA) with Terephthalic acid (TA) was obtained by the slow solvent evaporation and slurry crystallization methods. X-ray single crystal diffraction DPA:TA confirmed formation transfer an acidic proton from one carboxylic groups TA to tertiary amino group chain moiety (N3-nitrogen atom) DPA molecules. crystals crystalize in triclinic system space P-1. The asymmetric unit...

We concluded previously from mutagenesis in the intradiscal domain of bovine rhodopsin that the formation of a tertiary structure comprising the N-terminal tail and the three polypeptide loops is essential to the in vivo assembly of the functional rhodopsin. We now report on more comprehensive mutagenic studies in the intradiscal domain to determine more precisely the requirement for the format...

Polyethyleneimine (PEI) is a common polymer used in many industrial applications and research, especially surface chemistry. It available wide range of molecular weights different degrees branching. classified as linear or branched sometimes the term hyperbranched also used. This description, however, quite rough, which limits possibility to correlate structure PEI its properties. The aim this ...

results phylogenetic analysis of the gene revealed that pakistani 1a hcv strains are in the start of third cluster and there is a difference between inter pakistani isolates at primary, secondary and tertiary levels. material and methods patient sera infected with hepatitis c virus, genotype 1a, were obtained from molecular diagnostics lab, cemb, university of the punjab lahore by using bd vacu...

As globular proteins, enzymes have a specific three-dimensional shape which is determined by their sequence of amino acids. This specific tertiary structure is held together by ionic bonds, hydrogen bonds and disulphide bridges. Despite their generally large size, enzyme molecules have a small region that is functional, known as; the active site. The substrate molecule is held within the active...

Coupling of racemic N-protected amino acids with amino components by means of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) in the presence of chiral tertiary amines such as strychnine, brucine, and sparteine proceeds enantioselectively, affording appropriate amides or dipeptides in 69-85% yield. The configuration of the preferred enantiomer and enantiomeric enrichment depend on the structures o...